Understanding how neural progenitor cells develop in the brain
Transcriptional regulation of neural progenitor divisions and cell fate in the developing cortex
This study is looking at how brain cells develop in the early stages and how a specific protein called ZBTB7A might play a role in this process, which could help us understand conditions like autism and find new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project ID | NIH-11094102 on NIH RePORTER |
What this research studies
This research investigates the early stages of brain development, focusing on how neural progenitor cells (NPCs) divide and differentiate into various types of brain cells. By studying the role of a specific protein, ZBTB7A, in regulating these processes, the research aims to uncover the mechanisms that could lead to neurodevelopmental disorders like autism. The team uses advanced techniques, including genetic models and molecular assays, to analyze how changes in NPC behavior can affect brain structure and function. This work is crucial for identifying potential therapeutic targets for conditions associated with abnormal brain development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with autism spectrum disorder or related conditions.
Not a fit: Patients with neurodevelopmental disorders not related to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for neurodevelopmental disorders such as autism.
How similar studies have performed: Previous research has shown promising results in understanding the role of transcription factors in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Sioux Falls, United States
- Sanford Research/usd — Sioux Falls, United States (Active)
Researchers
- Principal investigator: Pilaz, Louis-Jan — Sanford Research/usd
- Study coordinator: Pilaz, Louis-Jan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.