Understanding how neural progenitor cells develop in the brain
Official title: Transcriptional regulation of neural progenitor divisions and cell fate in the developing cortex
Funded at Sanford Research/usd · NIH-11094102 · Data updated 2026-11-12
This study is looking at how brain cells develop in the early stages and how a specific protein called ZBTB7A might play a role in this process, which could help us understand conditions like autism and find new ways to help those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $415,000 |
| NIH project number | 5R01MH129419-03 |
| Project ID | NIH-11094102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with autism spectrum disorder or related conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not related to the mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the early stages of brain development, focusing on how neural progenitor cells (NPCs) divide and differentiate into various types of brain cells. By studying the role of a specific protein, ZBTB7A, in regulating these processes, the research aims to uncover the mechanisms that could lead to neurodevelopmental disorders like autism. The team uses advanced techniques, including genetic models and molecular assays, to analyze how changes in NPC behavior can affect brain structure and function. This work is crucial for identifying potential therapeutic targets for conditions associated with abnormal brain development.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for neurodevelopmental disorders such as autism.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Pilaz, Louis-Jan — Sanford Research/usd
- Study coordinator: Pilaz, Louis-Jan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.