How maternal diet affects heart health in children of diabetic mothers.
Official title: Dietary interventions to modulate heart health in offspring born to diabetic mothers and the subsequent generation.
Funded at Sanford Research/usd · NIH-11005213 · Data updated 2026-11-12
This study looks at how what mothers eat during pregnancy, especially if they have gestational diabetes or obesity, can affect the heart health of their children and even their grandchildren, using rats to find ways to help improve heart health for families at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | January 15, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $415,000 |
| NIH project number | 5R01HL160980-04 |
| Project ID | NIH-11005213 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are mothers with gestational diabetes or obesity, as well as their children and potentially their grandchildren.
✕Less likely to help
Patients who do not have a history of gestational diabetes or obesity may not benefit from this research.
What this research studies
This research investigates how the diets of mothers with gestational diabetes and obesity can impact the heart health of their children and even their grandchildren. By using a rat model, the study examines the effects of different maternal diets on the development of heart disease in offspring. The researchers aim to identify dietary interventions that can improve heart health outcomes for these at-risk populations, focusing on the mechanisms of heart disease programming and potential preventive measures.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that significantly reduce the risk of heart disease in children born to diabetic mothers.
How similar studies have gone: Previous research has shown that dietary interventions can positively influence heart health, suggesting that this approach may yield beneficial results.
Where this research is happening
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Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Baack, Michelle Leigh — Sanford Research/usd
- Study coordinator: Baack, Michelle Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.