How platinum chemotherapy reshapes the tumor's surrounding support in ovarian cancer
Elucidating spatiotemporal dynamics of nascent extracellular matrix in response to platinum treatment in ovarian cancer
['FUNDING_R37'] · SANFORD RESEARCH/USD · NIH-11330631
Researchers will track how platinum chemotherapy changes the tumor’s surrounding support structures in high-grade serous ovarian cancer to learn why tumors often return.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD RESEARCH/USD (nih funded) |
| Locations | 1 site (SIOUX FALLS, UNITED STATES) |
| Trial ID | NIH-11330631 on ClinicalTrials.gov |
What this research studies
This project uses laboratory models that mimic ovarian tumors, patient-derived tumor samples, and mouse-grown human tumors to follow newly made extracellular matrix after chemotherapy. Scientists will label newly produced proteins, image them with high-resolution microscopy, and analyze their composition using proteomics. The work combines engineered 3-D tumor co-cultures with patient and PDX biopsy material to link lab findings to real human tumors. Results aim to reveal when and where the tumor environment changes during and after platinum treatment.
Who could benefit from this research
Good fit: Ideal participants would be people with high-grade serous ovarian carcinoma who can provide tumor tissue or are treated at centers partnering with Sanford Research, especially those receiving platinum chemotherapy.
Not a fit: People without ovarian cancer or with non-high-grade serous subtypes are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could point to new ways to prevent or overcome chemotherapy resistance and lower the chance of ovarian cancer recurrence.
How similar studies have performed: Laboratory studies have linked extracellular matrix changes to chemotherapy resistance and related lab techniques have been used before, but applying detailed spatiotemporal tracking to patient tumors is relatively new.
Where this research is happening
SIOUX FALLS, UNITED STATES
- SANFORD RESEARCH/USD — SIOUX FALLS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE LA PUENTE, PILAR — SANFORD RESEARCH/USD
- Study coordinator: DE LA PUENTE, PILAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers