Molecular Regulators of Collecting Duct Remodeling
Funded at Sanford Research/usd · NIH-11295163 · Data updated 2026-11-12
A study with adults looking at how kidney collecting duct cells change and affect water balance, especially in people with Alagille syndrome or bipolar disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | August 5, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $586,408 |
| NIH project number | 1R01DK140395-01A1 |
| Project ID | NIH-11295163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Alagille syndrome or Alagille-Watson syndrome and those with bipolar disorder who may be affected by kidney water/ion balance.
✕Less likely to help
People without kidney or fluid-balance issues may not directly benefit.
What this research studies
This project explores how water channels in the kidney and the mix of cell types in the collecting duct influence water and salt balance, which can impact kidney health. It builds on findings that cell type changes and Notch signaling affect Aquaporin-2 and water reabsorption, and it considers how states like alkalosis or lithium treatment alter these processes. The researchers plan to use adult models to study the molecular pathways that control cell composition and transporter expression in the distal nephron. The work could help explain why certain medicines or conditions disrupt fluid balance and point to new targets for treating kidney-related complications.
Why it matters
Potential benefit: If successful, the work could lead to better understanding and treatment of kidney fluid balance disorders and drug-related kidney effects.
How similar studies have gone: Previous work shows that cell-type changes and Notch signaling influence water transport; this study extends those findings to human-relevant contexts.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Surendran, Kameswaran — Sanford Research/usd
- Study coordinator: Surendran, Kameswaran
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.