Sponsor or institution
Clinical trials and research at Oklahoma Medical Research Foundation
As of November 12, 2026, Find a Trial lists 2 clinical trials run by Oklahoma Medical Research Foundation that are recruiting, in United States. 1 was first registered in the last 30 days. There are also 147 NIH-funded research projects at this institution, with $91.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 2Clinical trials
- 147NIH research projects
- 1New in 30 days
- 1Country
All recruiting trials (2)
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Early start of Ocrevus Zunovo for relapsing MS
This study tests whether starting Ocrevus Zunovo soon after a relapse helps people with relapsing MS more than starting it later.
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Muscle aging and response to exercise in older adults with multiple sclerosis
This study will test whether a combined cardio and strength exercise program improves muscle health and fitness for people with MS who are 60 or older compared with similar people without MS.
NIH-funded research (newest 40 of 147)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how DIS3L2 helps keep RNA in check to help lupus patients
A physician-scientist team is studying how a watchdog molecule for RNA (DIS3L2) may drive lupus-related immune problems, with the goal of uncovering new paths to treatment.
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Stem cell mRNA marks and fat-infiltrated aging muscles
Researchers are studying how aging changes muscle at the cellular level, including fat and fibrous tissue buildup, to help keep older adults stronger and more mobile.
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Tissue research hub for autoimmune diseases to speed up new treatments
A national program is building a centralized tissue core to study autoimmune diseases like lupus, rheumatoid arthritis, Sjögren’s, and psoriatic conditions using advanced single-cell and spatial analysis.
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Roles of mitochondrial transporters SLC25A22 and SLC25A46 in brain health
This grant studies how two mitochondrial transporters, SLC25A22 and SLC25A46, affect brain metabolism and neurological disorders using fruit-fly models to uncover disease mechanisms.
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Colon mucus sugars and how they help keep gut bacteria and the colon healthy
Researchers are looking at how sugar-coated mucus made by cells in the front part of the colon helps keep gut bacteria balanced and may protect people with ulcerative colitis or pouch inflammation.
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Oxidized lipids driving aging-related muscle loss
This project explores how certain lipid molecules that are damaged or modified over time contribute to muscle weakness and loss in older adults, with the goal of identifying new ways to prevent sarcopenia.
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Novel pathways shaping facultative heterochromatin in cancer cells
This grant studies how certain chromatin regulators control cancer cell DNA packaging to reveal new angles for improving human health.
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Autophagy genes and lupus in African Americans
A study to understand how autophagy-related genes affect lupus in people, especially in African American patients.
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Understanding why sarcoidosis happens and how it affects people using multi-omics
A multi-omics study aims to uncover why sarcoidosis affects people differently and to find biomarkers that predict disease burden.
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How BET proteins control gene reading and DNA copying in cancer
This grant studies how specific chromatin readers called BET proteins help coordinate when genes are read and when DNA is copied, aiming to understand how disruptions can lead to cancer.
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Scalable tests to quickly study how gene variants affect biology
A research project to speed up how we study genetic variants and how they affect biology using zebrafish and new genome editing tools.
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SARM1's role in heart disease and metabolic diabetes
Aims to understand how a protein called SARM1 affects heart disease in people with diabetes, and whether stopping its activity could protect the heart.
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Metabolic controls on how lymphatic vessels form in cancer
A cancer-focused study is examining how the metabolism of lymphatic vessels affects their growth and how this could influence cancer spread and transplant rejection.
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Protease-Activated Receptor and Thrombomodulin Signaling in Blood Clotting and Cell Health
This grant explores how thrombomodulin and related proteins control blood clotting and protect blood vessel cells, with findings that could influence treatments for clotting disorders and vascular inflammation.
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Understanding how aging affects protein turnover in brain cells
Aging changes how proteins are broken down and rebuilt in brain cells, and this study explores why and how those changes happen.
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Mitochondria and how cells decide their fate
This grant studies how mitochondria influence how cells choose their identity and keep functioning, with potential implications for cancers.
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Gut microbes and multiple sclerosis progression: new clues from 16S sequencing
This grant explores how gut bacteria may influence how quickly multiple sclerosis progresses and how patients respond to therapies.
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Precision genome editing tools to study disease-related genetic variants in animals
A grant to develop and test advanced CRISPR-based tools in zebrafish so scientists can quickly and accurately figure out how human genetic variants affect disease.
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Genetic clues to metabolic resilience in cavefish
Researchers will study how cave-dwelling fish naturally tolerate high blood sugar and obesity to uncover clues for human metabolic health.
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Mapping how heterochromatin organizes itself in human cells
A project explores how tightly packed DNA (heterochromatin) organizes itself in human cells and what that means for gene regulation and disease.
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Artificial Intelligence and Machine Learning Core for Biomedical Genomics
A dedicated AI and machine learning core will help researchers use advanced AI methods to analyze high-throughput genomic data and imaging, improving their chances to secure larger grants and advance patient-focused science.
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Epigenomics Core: newer DNA regulation services for researchers
A core facility upgrade at a medical research center will add advanced DNA accessibility, protein binding, and long-read sequencing services to support genomic regulation and immunity studies.
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Administrative Core of a Center on Chromatin and Epigenetic Regulation
An Administrative Core helps run a center focused on how chromatin and epigenetic changes control genome function, supporting early-career researchers and guiding pilots and cores toward impactful discoveries.
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Center for Genomic Regulation in Oklahoma
A multi-year program to build a collaborative genomics research hub in Oklahoma that connects experts to study how genomes are controlled and ultimately improve cancer biology.
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Understanding chromosome movements in mouse eggs to prevent birth defects
Researchers are studying how chromosomes move during egg development in mice to better understand why embryos sometimes have the wrong number of chromosomes, which can lead to pregnancy loss or birth defects.
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S1PR1 signaling in lymphatic vessels may shape immune structures in the gut
This project looks at a specific molecule in the lymphatic vessels to understand how immune cell clusters form in the gut and what that means for inflammatory bowel diseases.
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Understanding how cells divide and ensure chromosomes move correctly
A study to uncover how cells carefully manage chromosome movement during division, which could help explain why errors occur in cancer and birth defects.
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Understanding how progranulin deficiency worsens lupus-related brain disease
This grant looks at how a specific protein deficiency may worsen brain and nerve system problems in lupus patients, with a focus on potential new ways to treat NPSLE.
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Endothelial MEKK3 signaling and vascular remodeling
A study in people with vascular disease factors aims to understand how blood vessel lining cells sense blood flow and decide when to stay stable or remodel.
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PFKFB3's role in keeping blood vessels tight during inflammation
This grant explores how a metabolic regulator called PFKFB3 affects the lining of blood vessels during inflammation, with the goal of preventing leaks that can worsen disease.
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Molecular and Cellular Phenotyping Core for metabolism research
A new core service is being added to help researchers study which genes and proteins change in tissues and what those changes mean, using advanced imaging and tissue techniques.
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Metabolic Phenotyping Core supports autoimmune and metabolic research in Oklahoma
A research center in Oklahoma is expanding a dedicated Metabolic Phenotyping Core to help scientists study how cellular metabolism relates to autoimmune diseases and other conditions.
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Flow Cytometry Core for Advanced Cellular Analysis
This grant funds a long‑standing Flow Cytometry Core to provide researchers with access to state‑of‑the‑art cell analysis and sorting tools, guidance, and methods support.
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Administrative Core supports a regional biomedical center in cellular metabolism
A center-wide backbone grant helps Oklahoma researchers coordinate and grow metabolism-related studies for people in the region.
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Center for Cellular Metabolism Research in Oklahoma Expansion
A center in Oklahoma is expanding its work on how cell metabolism affects diseases like heart disease, autoimmune disorders, and diabetes to help patients in the region.
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Oklahoma ACE: Targeting autoimmune disease biology to improve clinical trial success
A new NIH grant aims to understand autoimmune diseases better by linking patient data with lab studies to design smarter trials and treatments.
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Ketogenic diet for autoimmune eye and nerve health
A well-formulated ketogenic diet aims to lower inflammation and help protect vision and nerves in people with autoimmune conditions like multiple sclerosis.
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How some HIV medicines might harm the heart
Looking at whether certain HIV drugs cause heart scarring and raise the risk of sudden death for people living with HIV.
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Central tissue hub for lupus, rheumatoid arthritis, Sjögren’s, and psoriatic disease
This project collects and shares high-quality tissue and blood samples from people with lupus, rheumatoid arthritis, Sjögren’s, and psoriatic disease so researchers can develop better tests and treatments.
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Blocking complement protein C5 to treat sepsis
This project looks at whether blocking a part of the immune system called complement C5 can help people with severe sepsis avoid organ failure.
Quick answers
How many clinical trials run by Oklahoma Medical Research Foundation are recruiting right now?
2, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.