Autophagy genes and lupus in African Americans
Official title: Contributions of autophagy-related genes in lupus
Funded at Oklahoma Medical Research Foundation · NIH-11388651 · Data updated 2026-11-12
A study to understand how autophagy-related genes affect lupus in people, especially in African American patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $751,755 |
| NIH project number | 5R01AI172255-04 |
| Project ID | NIH-11388651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lupus (SLE), especially those of African American descent, who may contribute genetic samples or clinical data.
✕Less likely to help
Non-lupus individuals or lupus patients who do not meet participant criteria may not benefit.
What this research studies
This project looks at how cellular cleanup genes (autophagy) may influence lupus, a disease that can damage multiple organs. Researchers will examine genetic data and cellular mechanisms to connect gene variants with how lupus develops in patients. The study will involve analysis of human samples and data from individuals with lupus, with attention to ethnic differences. Results could point to new ways to predict risk or tailor treatments for those most affected. The work is conducted at a major medical research center with strong collaboration across specialties.
Why it matters
Potential benefit: If successful, it could lead to better risk prediction and more personalized therapies for lupus, particularly in African American patients.
How similar studies have gone: Previous genetic and autophagy studies in lupus have identified associations, but causal mechanisms remain to be clarified in humans.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Nath, Swapan K. — Oklahoma Medical Research Foundation
- Study coordinator: Nath, Swapan K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.