Endothelial MEKK3 signaling and vascular remodeling
Official title: The role of endothelial MEKK3 signaling in pathological vascular remodeling
Funded at Oklahoma Medical Research Foundation · NIH-11336058 · Data updated 2026-11-12
A study in people with vascular disease factors aims to understand how blood vessel lining cells sense blood flow and decide when to stay stable or remodel.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | February 5, 2021 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $306,900 |
| NIH project number | 2P20GM139763-06 |
| Project ID | NIH-11336058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with vascular malformations or related blood vessel conditions who could contribute tissue samples or participate in mechanistic studies.
✕Less likely to help
People without vascular conditions may not directly benefit, as the work focuses on mechanisms of vessel remodeling.
What this research studies
Endothelial cells sense the forces from blood flow and use signaling pathways to decide whether vessels should stay steady or change shape. This project explores how MEKK3-related signaling controls key factors like KLF2/4 that govern vascular behavior under different flow conditions. By examining the MEKK2/3-p62 complex and its role in shear sensing, researchers hope to clarify why some vessels become malformed. The findings could pave the way for therapies that prevent or correct abnormal vessel remodeling in patients with vascular diseases.
Why it matters
Potential benefit: If successful, this work could lead to new approaches to prevent or treat abnormal blood vessel remodeling in patients with vascular disorders.
How similar studies have gone: Previous work has shown MEKK3-related pathways influence vascular signaling, with ongoing efforts building on these insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Coon, Brian Gene — Oklahoma Medical Research Foundation
- Study coordinator: Coon, Brian Gene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.