Muscle aging and response to exercise in older adults with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The investigators will first compare baseline muscle and cardiovascular health in adults aged 60 and older with MS to age-matched people without MS. Participants will then complete a combined cardiovascular and resistance training program with visits about three times per week, roughly 1.5 hours per visit, for approximately four months. The study will measure whole-body and muscle-specific changes, including differences between a more affected and a less affected leg in people with MS, and cardiorespiratory fitness (VO2max). Results will show whether older adults with MS adapt to exercise differently than age-matched peers without MS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Male or female aged 60 or above 2. Free of unmanaged chronic diseases other than multiple sclerosis 3. No structured exercise program (2 or more bouts/wk) within previous 6 months 4. Cognitively capable of providing informed consent 5. Must meet EDSS score between 2 to 5.5 during screening

Exclusion Criteria:

* 1\. Neuromuscular or musculoskeletal disorder, other than multiple sclerosis, that would limit the ability to perform the exercise and/or testing bouts.

  2\. Cardiopulmonary disorders or reduced breathing capacity

  3\. Metabolic diseases including markers of liver disease (ALT \> 52 U/dl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)

  4\. Taking any dose of metformin

  5\. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, Alzheimer's, current cancer diagnosis or within 2 yr remission, cerebrovascular)

  6\. History of Chemotherapy within 5 years

  7\. Unchangeable anticoagulant (Coumadin, Pradaxa, etc.) use. To be determined by clinical staff.

  8\. Insulin sensitizing/blood glucose lowering (e.g., metformin) or metabolic (GLP1 agonists) drugs.

  9\. High dose statin (40 mg and above)

  10\. Have a non-correctable visual impairment

  11\. Score less than 29 on the Symbol Digit Test

  12\. Received Botox for spasticity within the prior 3 months of study participation.

  13\. Cannot have any adjustments to Baclofen during study participation.

  13\. Unable to commit to \~4 months required to complete the study.

  14\. Lidocaine allergy

  15\. Tobacco use

  16\. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/day or drinks/wk for males)

  17\. BMI greater than 35.0 kg/m2

Where it's running

• Oklahoma Medical Research Foundation
  Oklahoma City, Oklahoma, United States Recruiting

Study contacts

• Principal investigator: Benjamin F Miller, Ph.D. — Oklahoma Medical Research Foundation
• Study coordinator: Lena Fuentes
• Email: lena-fuentes@omrf.org
• Phone: 4052717745

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.