S1PR1 signaling in lymphatic vessels may shape immune structures in the gut
Official title: S1PR1 Signaling In The Lymphatic Vasculature Regulates Tertiary Lymphoid Organ Formation
Funded at Oklahoma Medical Research Foundation · NIH-11346823 · Data updated 2026-11-12
This project looks at a specific molecule in the lymphatic vessels to understand how immune cell clusters form in the gut and what that means for inflammatory bowel diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 15, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $676,865 |
| NIH project number | 1R01HL185377-01 |
| Project ID | NIH-11346823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with inflammatory bowel diseases or related gut inflammatory conditions to inform future translational work, biomarkers, or therapies.
✕Less likely to help
Patients without inflammatory bowel conditions may not directly benefit from this specific basic science investigation.
What this research studies
Researchers will study how S1PR1 in lymphatic endothelial cells influences the development of tertiary lymphoid organs in the gut and how these structures relate to intestinal inflammation. They will use mouse models to test how S1PR1 deficiency affects TLO formation, microbiota interactions, and antigen-presenting cell activity. Three aims will explore the role of TLOs in gut disease, the influence of gut microbes and immune cells on TLO development, and the cellular mechanisms by which S1PR1 controls this process. The work aims to uncover new angles for treating inflammatory bowel diseases beyond current immunosuppressive drugs.
Why it matters
Potential benefit: If successful, the findings could point to new ways to manage gut inflammation by guiding TLO formation and lymphatic signaling.
How similar studies have gone: Previous work shows that lymphatic signaling influences immune organization in tissues, but the precise role of S1PR1 in gut TLOs is not yet established.
Where this research is happening
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Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Srinivasan, Rajanarayanan S — Oklahoma Medical Research Foundation
- Study coordinator: Srinivasan, Rajanarayanan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.