Sponsor or institution
Clinical trials and research at East Carolina University
As of November 12, 2026, Find a Trial lists 7 clinical trials run by East Carolina University that are recruiting, in United States. There are also 46 NIH-funded research projects at this institution, with $17.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 7Clinical trials
- 46NIH research projects
- 1Country
Newest trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Choline education during pregnancy to help placentas and newborns | — | Greenville, North Carolina | Recruiting | Apr 13, 2026 |
| Remote blood-flow conditioning plus balance training for children with cerebral palsy | — | Greenville, North Carolina | Recruiting | Feb 5, 2026 |
| Improving a smartphone toolkit to help adolescent and young adult cancer survivors manage depression | — | Greenville, North Carolina and 1 other locations | Recruiting | Sep 15, 2025 |
| Examining the effects of different exercise modes during pregnancy on maternal and infant health | — | Greenville, North Carolina | Recruiting | Sep 19, 2024 |
| Exercise to Reduce PreEclampsia Risk in Pregnant Women | — | Greenville, North Carolina | Recruiting | Mar 19, 2024 |
| Effects of different exercise modes during pregnancy on childhood obesity | — | Greenville, North Carolina | Recruiting | Mar 18, 2021 |
| Muscle energy use and its link to metabolic inflexibility | — | Greenville, North Carolina | Recruiting | Mar 24, 2020 |
All recruiting trials (7)
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Choline education during pregnancy to help placentas and newborns
This trial will test whether giving pregnant people choline nutrition education increases their choline levels and improves placental function and newborn body composition.
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Remote blood-flow conditioning plus balance training for children with cerebral palsy
This study will test whether brief, safe cycles of limb blood-flow restriction combined with balance training can change spinal reflexes and improve balance in children with cerebral palsy aged 8–17.
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Improving a smartphone toolkit to help adolescent and young adult cancer survivors manage depression
This project will test parts of a digital toolkit to see which pieces help adolescent and young adult cancer survivors reduce symptoms of depression.
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Examining the effects of different exercise modes during pregnancy on maternal and infant health
This study is testing how different types of exercise during pregnancy can affect the health of both mothers and their babies.
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Exercise to Reduce PreEclampsia Risk in Pregnant Women
This study is testing whether different types of exercise can help pregnant women at risk for preeclampsia have healthier pregnancies and better outcomes for their babies.
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Effects of different exercise modes during pregnancy on childhood obesity
This study is testing how different types of exercise during pregnancy can affect the health of overweight and obese moms and their babies to see which workouts are best for preventing childhood obesity.
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Muscle energy use and its link to metabolic inflexibility
This study will test whether overweight adults (BMI 25–30) with higher fasting lactate rely more on anaerobic muscle metabolism and are more prone to metabolic inflexibility compared with low‑lactate overweight and severely obese participants.
NIH-funded research (newest 40 of 46)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how metal ions trigger transthyretin misfolding and toxic clumps in degenerative diseases
This grant looks at how metal ions like zinc and calcium may cause the protein transthyretin to misfold and form harmful clumps that could contribute to conditions like cardiomyopathy and nerve disease.
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BipA’s role in Yersinia pestis causing pneumonic plague
A small NIH-funded project will explore how a bacterial protein called BipA helps Yersinia pestis cause severe lung infection in mice.
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Noninvasive blood pressure and biomarker panel using AI-enhanced 2-site PPG
Aims to create a portable, noninvasive device that uses optical signals to estimate blood pressure, blood glucose, and arterial health markers for people at risk of cardiometabolic diseases.
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Optogenetic study of EPHA1 mutations linked to Alzheimer's disease
A patient-friendly look at how specific EPHA1 gene changes found in some people with Alzheimer’s might affect brain cells, using light-activated receptors to map their effects.
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Improving glaucoma risk predictions using diverse genetic data
A glaucoma study uses genetic data from people of African, American, and European ancestry to build better risk scores and help with early detection.
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How brain cleanup after injury works and what helps it
Researchers are studying how brain cleaning cells remove dead cells after a traumatic brain injury and whether a protein called MERTK helps or hinders this process to support recovery.
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Role of Annexin A1 in HTLV-1–related blood cancer progression
A small NIH-funded project looks at how a protein called Annexin A1 may influence the progression of HTLV-1–associated leukemia and how it relates to chemotherapy effects in affected patients.
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Understanding how Brucella gene silencing affects its ability to cause disease
Scientists are studying Brucella bacteria to uncover how a protein called MucR helps the bacteria turn off genes and how this affects its ability to cause illness in animals and people.
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Prenatal exercise modes and how they affect child obesity risk
This study tests which exercise type during pregnancy best protects children from obesity and metabolic problems later in life for women who are overweight or obese.
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Picking healthier sperm by their metabolism to improve fertility treatments
This project uses sperm metabolism and movement patterns to pick sperm that may help couples using IVF/ICSI produce more healthy embryos.
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Metformin exposure in pregnancy and its effects on child growth and metabolism
This grant will study how taking metformin during pregnancy affects a child’s growth and metabolism, from infancy through childhood.
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Antibacterial dental filling ingredient to prevent decay around fillings
A new ingredient added to adult resin fillings designed to stop harmful bacteria from building up around the filling and help prevent repairs.
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How exercise during pregnancy in people with obesity affects babies' stem cells
This project looks at whether aerobic or resistance exercise during pregnancy in people with obesity changes newborns' stem cells that are linked to body fat and metabolism.
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How Lyme bacteria's internal tails let them move and cause joint infections
Researchers are learning how the corkscrew motion and internal tail structures of Lyme bacteria help them reach and damage joints in people with Lyme disease.
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iManageAYA: a smartphone program to help young cancer survivors with depressive symptoms
This project will create and refine a mobile app to help adolescent and young adult cancer survivors manage depressive symptoms on-demand.
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Understanding how certain cells help HIV spread and establish latency
This study is looking at how certain cells in your lymph nodes might make it easier for HIV to spread and hide in your body, which could help us find better ways to treat and prevent the virus in people living with HIV.
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How fibrinogen becomes fibrin and why that matters for blood clots
We are finding molecular differences between fibrinogen and fibrin to help people with clot-related problems like heart disease, stroke, and Alzheimer’s-related vascular damage.
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Understanding how a protein called MucR helps Brucella bacteria cause illness
This research aims to understand how a specific protein in Brucella bacteria helps them cause brucellosis, a serious infection in animals and people.
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Improving sperm selection to enhance assisted reproduction success
This study is looking at ways to improve fertility treatments by finding sperm that are more likely to lead to successful pregnancies, which could help families have healthier embryos and reduce the number of treatment cycles they need.
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How different types of exercise during pregnancy affect childhood obesity risk
This study is looking at how different types of exercise during pregnancy can help reduce the risk of childhood obesity, especially for moms who are overweight or obese, and it aims to find out which exercises are best for both moms and their babies.
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Understanding how a specific potassium channel affects recovery from spinal cord injuries
This study is looking at how a specific gene affects healing after spinal cord injuries, using zebrafish to see if changing this gene or using a special medication can help improve recovery, with the hope of finding new treatments for people with spinal cord injuries.
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Understanding how a specific protein helps bacteria cause pneumonic plague
This study is looking at how a specific protein from the bacteria that causes pneumonic plague helps it hide from the body's defenses in the lungs, and it aims to find new ways to treat this serious infection.
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Understanding unique proteins that help spirochetes move
This study is looking at special proteins that help the Lyme disease bacteria move, with the goal of understanding how they work so we can find better ways to treat infections caused by these germs.
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Using a new chemical to improve dental materials and prevent cavities.
This study is looking at new dental materials that can help stop cavities from forming under fillings, so patients can enjoy longer-lasting dental work and a lower chance of getting new cavities.
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How exercise during pregnancy affects the metabolism of babies born to obese mothers
This study is looking at how different types of exercise during pregnancy can help improve the health of babies born to moms with obesity by examining the stem cells from their umbilical cords.
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Improving risk prediction for glaucoma in diverse populations
This study is looking to improve how we predict the risk of primary open-angle glaucoma in people of African ancestry, so that they can get better early diagnosis and treatment options based on their unique genetic background.
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Using collagen-derived peptides to reduce inflammation after heart attacks
This study is looking at a special protein that might help reduce harmful inflammation after a heart attack, making it easier for your heart to heal while still doing its important repair work.
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Developing a mobile app to help young cancer survivors manage depression
This study is testing a new mobile app that helps young people who have survived cancer manage feelings of sadness, making it easier for them to find support and resources whenever they need it.
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Understanding how children's throat muscles work during speech using MRI
This study is looking at how children with cleft palate or speech issues use their throat muscles when they talk, using special imaging to see how everything works, so doctors can better plan treatments and surgeries for them.
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Improving dental health for pregnant women and their children
This study is all about helping low-income pregnant women get the dental care they need by listening to their stories and experiences, so we can find better ways to support them and their children in taking care of their teeth.
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Understanding how certain bacteria form protective communities that can cause infections.
This study is looking at how certain bacteria, which aren't cholera but can still cause infections, stick together to form protective groups called biofilms, and it aims to understand a specific protein that helps these bacteria create their protective layers, which could lead to better ways to fight these infections.
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Exploring a unique muscle that survives without oxygen
This study is looking at a special kind of muscle that can survive with less oxygen, which could help find new ways to treat people with conditions like peripheral artery disease and muscle disorders.
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Understanding how a specific receptor affects high blood pressure
This study is looking at how a specific receptor in the body might contribute to high blood pressure by causing inflammation in the brain, and it aims to find new ways to help manage hypertension that could lead to better treatments for patients.
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Understanding how a protein affects the virulence of Brucella bacteria
This study is looking at a protein called MucR in Brucella bacteria, which cause a disease that can spread from animals to humans, to understand how it helps the bacteria become more harmful and to find ways to treat the illness better.
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Better genetic risk prediction for open-angle glaucoma
This project will build more accurate genetic risk tools for people at risk of open-angle glaucoma by including more diverse ancestry groups in the analysis.
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Investigating how fibrin fibers form and break down in blood clots
This study is looking at how blood clots form and break down, which is important for people with conditions like diabetes and heart disease, to help find better ways to diagnose and treat these issues.
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Impact of La Crosse encephalitis on communities in western North Carolina
This study looks at how La Crosse encephalitis, a virus that mainly impacts kids in western North Carolina, affects families and communities, especially those with fewer resources, while also checking how mosquitoes relate to the spread of the disease to find better ways to prevent and treat it.
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Understanding how stem cells interact with their environment during organ development.
This study is looking at how stem cells talk to the cells around them while organs are developing, using fruit flies to learn more about how these cells move and work together, which could help us understand healing and growth in the body better.
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Using backpack hydration systems to help farmworkers stay hydrated
This study is looking at how to make it easier for farmworkers to stay hydrated while they work in the heat by using special backpack water systems, and it will involve talking to farmworkers to understand their needs and measuring how well these systems help them drink enough water.
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Creating a special mouse model to study ataxin-1's role in diseases.
This study is creating a special mouse model to learn more about a protein called ataxin-1, which is important for brain health and may be linked to diseases like Alzheimer's, so we can better understand how it works and help people with these conditions.
Quick answers
How many clinical trials run by East Carolina University are recruiting right now?
7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.