Understanding how a specific receptor affects high blood pressure
Official title: Neuroimmune Mechanisms of Kinin B1 Receptor in Hypertension
Funded at East Carolina University · NIH-10895459 · Data updated 2026-11-12
This study is looking at how a specific receptor in the body might contribute to high blood pressure by causing inflammation in the brain, and it aims to find new ways to help manage hypertension that could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Carolina University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project start | August 15, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $368,750 |
| NIH project number | 5R01HL153115-05 |
| Project ID | NIH-10895459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypertension who may not be adequately managed by current therapies.
✕Less likely to help
Patients with normal blood pressure or those whose hypertension is well-controlled with existing treatments may not benefit from this research.
What this research studies
This research investigates the role of the kinin B1 receptor in hypertension, focusing on how its activation can lead to increased inflammation in the brain, particularly in areas that regulate blood pressure. The study aims to explore the mechanisms by which this receptor interacts with other proteins involved in blood pressure regulation. By examining both pharmacological and genetic approaches to inhibit this receptor, the research seeks to identify new therapeutic strategies for managing hypertension. Patients may benefit from insights that could lead to more effective treatments for high blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve blood pressure management and reduce complications associated with hypertension.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for hypertension treatment, indicating potential for success in this approach.
Where this research is happening
-
East Carolina University
Greenville, United States Active
Researchers
- Principal investigator: Sriramula, Srinivas — East Carolina University
- Study coordinator: Sriramula, Srinivas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.