Using collagen-derived peptides to reduce inflammation after heart attacks

Who could benefit from this research

What this research studies

This research investigates the use of a specific peptide derived from collagen to target inflammation following a myocardial infarction (heart attack). The approach focuses on modulating the activity of matrix metalloproteinase-9 (MMP-9), which plays a crucial role in the healing process but can also contribute to adverse heart remodeling. By using the peptide p1159, the research aims to reduce harmful inflammation while allowing MMP-9 to perform its necessary functions in tissue repair. This could lead to improved outcomes for patients recovering from heart attacks.

Why it matters

Where this research is happening

• East Carolina University
  Greenville, United States Active

Researchers

• Principal investigator: De Castro Braz, Lisandra E — East Carolina University
• Study coordinator: De Castro Braz, Lisandra E

Related research

Other NIH-funded projects on the same topics.

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  NIH research Washington University · Saint Louis, United States · NIH-11432693

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• Real-time multi-lead ECG from wearables to help detect heart attacks early

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  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11417336

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.