Using collagen-derived peptides to reduce inflammation after heart attacks
Collagen-derived peptides to target inflammation in myocardial infarction
['FUNDING_R01'] · EAST CAROLINA UNIVERSITY · NIH-10980527
This study is looking at a special protein that might help reduce harmful inflammation after a heart attack, making it easier for your heart to heal while still doing its important repair work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EAST CAROLINA UNIVERSITY (nih funded) |
| Locations | 1 site (GREENVILLE, UNITED STATES) |
| Trial ID | NIH-10980527 on ClinicalTrials.gov |
What this research studies
This research investigates the use of a specific peptide derived from collagen to target inflammation following a myocardial infarction (heart attack). The approach focuses on modulating the activity of matrix metalloproteinase-9 (MMP-9), which plays a crucial role in the healing process but can also contribute to adverse heart remodeling. By using the peptide p1159, the research aims to reduce harmful inflammation while allowing MMP-9 to perform its necessary functions in tissue repair. This could lead to improved outcomes for patients recovering from heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are at risk of developing heart failure.
Not a fit: Patients who have not had a heart attack or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce the risk of heart failure after a heart attack.
How similar studies have performed: Previous research has shown promise in targeting MMP-9 for cardiac conditions, but this specific approach using collagen-derived peptides is novel.
Where this research is happening
GREENVILLE, UNITED STATES
- EAST CAROLINA UNIVERSITY — GREENVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE CASTRO BRAZ, LISANDRA E — EAST CAROLINA UNIVERSITY
- Study coordinator: DE CASTRO BRAZ, LISANDRA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.