Using a new chemical to improve dental materials and prevent cavities.
Addition of a Reverse Amide to Methacrylate-Based Dental Materials to Inhibit Microbial Biofilm Formation.
This study is looking at new dental materials that can help stop cavities from forming under fillings, so patients can enjoy longer-lasting dental work and a lower chance of getting new cavities.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Carolina University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project ID | NIH-11037538 on NIH RePORTER |
What this research studies
This research focuses on developing dental materials that can effectively prevent secondary caries, which are cavities that form under existing fillings. The approach involves adding a specific chemical, known as a reverse amide, to methacrylate-based dental materials to inhibit the growth of harmful bacteria while preserving beneficial ones. By testing these materials in water-based solutions, the researchers aim to create a more effective barrier against biofilm formation, which is a major cause of dental decay. Patients may benefit from longer-lasting dental fillings and reduced risk of cavities.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who have existing dental fillings and are at risk for secondary caries.
Not a fit: Patients who do not have dental fillings or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dental materials that significantly reduce the incidence of secondary caries, improving oral health outcomes for patients.
How similar studies have performed: Previous research has shown promise in using antimicrobial agents in dental materials, but this specific approach with reverse amides is relatively novel.
Where this research is happening
Greenville, United States
- East Carolina University — Greenville, United States (Active)
Researchers
- Principal investigator: Geraldeli, Saulo — East Carolina University
- Study coordinator: Geraldeli, Saulo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.