Investigating how fibrin fibers form and break down in blood clots
Official title: How do early stages of fibrin fiber assembly affect clot structure and lysis
Funded at East Carolina University · NIH-10875762 · Data updated 2026-11-12
This study is looking at how blood clots form and break down, which is important for people with conditions like diabetes and heart disease, to help find better ways to diagnose and treat these issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | East Carolina University NIH-funded |
| Lab location | 1 site (Greenville, United States) |
| Project start | July 1, 2019 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $455,082 |
| NIH project number | 2R15HL148842-02 |
| Project ID | NIH-10875762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiovascular diseases or conditions that affect blood clotting, such as diabetes.
✕Less likely to help
Patients with no history of cardiovascular issues or blood clotting disorders may not benefit from this research.
What this research studies
This research focuses on understanding the processes that regulate the formation and breakdown of fibrin fibers, which are crucial for blood clotting. By examining how fibrinogen transforms into fibrin and how these fibers assemble into a gel-like structure, the study aims to uncover the factors that influence clot stability and digestion. The research employs advanced techniques to analyze the polymerization of fibrin and its implications for conditions like diabetes and cardiovascular diseases. Ultimately, the goal is to improve diagnostic and treatment strategies for these health issues.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for cardiovascular diseases and related conditions.
How similar studies have gone: Previous research has shown promising results in understanding fibrin polymerization, but this specific approach to studying early fibrin assembly is relatively novel.
Where this research is happening
-
East Carolina University
Greenville, United States Active
Researchers
- Principal investigator: Hudson, Nathan — East Carolina University
- Study coordinator: Hudson, Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.