Sponsor or institution
Clinical trials and research at Children's Hosp of Philadelphia
As of November 12, 2026, Find a Trial lists 730 NIH-funded research projects at this institution, with $489.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 730NIH research projects
NIH-funded research (newest 40 of 730)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Emotional and biobehavioral links in parent-infant closeness
A program to understand how parent and baby feel and react to each other in early life, with the goal of guiding better child social and emotional development.
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Leukodystrophy Clinical Careers and Mentorship Network
A program to train, mentor, and support clinicians and researchers to advance care for people with leukodystrophies.
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Role of ATP1A3 mutations in sudden death related to epilepsy
Aims to understand how ATP1A3 gene changes may lead to sudden death in kids with epilepsy and is exploring new ways to prevent it.
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Kids First Data Resource Center: cloud-enabled data sharing for childhood cancer research
A data resource project that makes pediatric cancer data and analyses more accessible to researchers, with the goal of advancing understanding and care for children with cancer.
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PROMISE: A Network for Real-World Evidence in Rare Pediatric Cancers
A network will collect and harmonize pediatric cancer patient records from multiple centers to create high-quality real-world data that can support quicker, regulatory-ready insights when randomized trials aren’t feasible.
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Data Hub Core for Down syndrome research
A data hub project is building a big, interoperable platform to securely share and analyze information from people with Down syndrome and related conditions.
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INCLUDE Data Coordinating Center for Down syndrome research
A national coordinating center is funded to organize and share data from studies about Down syndrome and related conditions to help people with DS and their families.
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Personalized care for septic children through immunomodulation in MODS
This project tests a custom approach to treating pediatric sepsis in kids with organ failure by tailoring treatments to each child’s immune profile.
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Kids First Pediatric Data Resource Center accelerates collaborative data discovery for childhood development and cancer
A large, openly shared collection of kids’ genomic and clinical data is being expanded to help researchers uncover better ways to understand and treat childhood diseases including cancer.
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ALLY-DS: Improving health and daily life for youth and adults with Down syndrome
A nationwide effort to study health and well-being in people with Down syndrome across childhood through adulthood, with aims to better understand and support co-occurring conditions.
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NextGen - CHOP: Advanced T-cell Therapies for Pediatric Cancers
A patient-focused program aims to develop next-generation engineered T-cell therapies to treat childhood solid tumors and B-cell leukemias, with a plan to move toward routine use within a decade.
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Multimodal AI to diagnose and understand inherited craniofacial conditions
A new AI-powered system will combine facial photos, clinical data, and genetic information to help diagnose congenital craniofacial conditions in newborns.
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Data Hub Core for Down Syndrome Research and Collaboration
A secure, interconnected data platform is being built to connect genetic, clinical, imaging, and other data from people with Down syndrome to help researchers, clinicians, and families accelerate discoveries and trials.
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Data Management Core for Down syndrome research data coordination
A data management core helps researchers studying Down syndrome share, organize, and use data in a secure, open way to advance discoveries.
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Include Data Coordinating Center for Down syndrome research
A national program is funding a Data Coordinating Center to organize and share information about co-occurring conditions in people with Down syndrome to accelerate discoveries and improve lives.
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IDDRC at CHOP/Penn: Advancing understanding and treatment of intellectual and developmental disabilities
A grant supplement supports CHOP and Penn researchers in continuing a big, collaborative program to study the causes, brain changes, and potential treatments for intellectual and developmental disabilities.
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Healthy Brain and Child Development for the next generation
A large, long-term study follows thousands of mothers and young children to map how brain development unfolds from birth through early childhood in diverse families.
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Designing T-cell receptors to recognize cancer targets
This project will combine large lab datasets, structural studies, and machine learning to create T-cell receptors that can find cancer antigens for people with cancer.
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Genome-informed risk reports for chil dren and adults using polygenic scores
This project shares genome-informed risk scores and reports with patients and clinicians to help understand hereditary and polygenic risk for autoimmune diseases and related conditions.
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Understanding early Friedreich ataxia in children to improve how we measure outcomes
This study looks at how Friedreich ataxia starts and progresses in kids to create better, child-friendly measures for tracking the disease and testing treatments.
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Social connections and quality of life for kids who survived brain cancer
This project follows pediatric brain cancer survivors as they grow into adults to understand how their social connections affect their happiness and mental well-being.
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Precise measure of how CP affects movement to guide treatment
Aims to create precise, child-friendly ways to measure selective motor control in cerebral palsy so treatment can be tailored to each child.
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Tracking antibiotic-resistant bacteria in community and hospital wastewater
This project uses regular wastewater checks to track antibiotic-resistant bacteria in communities and hospitals to help protect patients.
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BrighT STAR SIRIUS: a toolkit to cut unnecessary blood cultures in sick kids
A multi-site study is testing a toolkit to reduce unnecessary blood culture tests in critically ill children to prevent unnecessary treatments and harms.
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Wearable sensors to track activity and predict worsening in pediatric pulmonary hypertension
A pediatric-focused study will use wearable activity trackers and cloud-based data analysis to help predict when a child with pulmonary hypertension may worsen.
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DECIDES 2.0: a decision aid to empower adolescents and young adults with cancer
A new, easy-to-use online and mobile tool helps teens and young adults with cancer make informed treatment choices together with their families and doctors.
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Energy use in bone-breaking cells during male bone loss
A study in mice looks at how bone-resorbing cells use energy, especially in the context of aging and low male hormones, to understand why osteoporosis happens in men.
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Engineering CD19 mimotopes to boost and broaden CD19-CAR T cell therapy
A patient-focused look at improving existing CD19-CAR T cell therapy so more people with blood cancers might benefit.
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Light exposure and sleep in teens with migraine
Teens with migraine and light sensitivity will wear sensors to track daily light and sleep, helping researchers understand how light exposure affects symptoms and nighttime rest.
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New noninvasive brain-monitoring tech to help kids after traumatic brain injury
A new noninvasive optical device is being developed to detect brain problems early in children who have suffered a traumatic brain injury.
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Chromatin remodelers and blood disorders: how BRG1/BRM shape hemoglobin production
A study to understand how chromatin remodeling proteins control red blood cell development and fetal vs. adult hemoglobin, with potential implications for diseases like sickle cell and beta-thalassemia.
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AxTRAORDINARY: testing targeted therapies for youth with axial spondyloarthritis
A study in children and adults with axial spondyloarthritis will explore a newer oral therapy (a JAK-STAT inhibitor) to find better, more personalized treatments beyond current options.
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Early ID and Prevention of Type 1 Diabetes with Genetic Risk Screening and CAR-T-reg Therapy
A pediatric-focused program aims to identify children at high risk for Type 1 diabetes using genetic risk scores and deliver a novel CAR-T-reg cell therapy to prevent the disease.
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Precision check of how kids push to poop (defecation) in dyssynergic defecation
A child-friendly study uses a tiny, electronic stool-shaped device to watch how kids with certain bowel problems push and coordinate during bowel movements.
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Computational methods to design new immunotherapies for childhood cancer
A pediatric cancer program is using advanced computer tools to find new immune-based treatments for children with neuroblastoma and related cancers.
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Antibiotic Dosing in Critically Ill Children with Pneumonia
This project studies how antibiotics reach the lungs of very sick children with bacterial pneumonia and aims to find the best dosing to treat severe infections.
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Non-invasive tests to find foods causing EoE in kids
A pilot study to test new, non-invasive methods that identify foods causing eosinophilic esophagitis in children.
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Understanding how bone marrow supports newborn blood formation after illness
Researchers will study how newborns’ bone marrow environment changes after severe infections to better protect and rebuild blood formation later in life.
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Targeted role of Intelectin-1 in protecting against obesity
A small, patient-friendly study to understand how a natural body protein, Intelectin-1 (ITLN1), could help prevent obesity.
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Influenza, Hydroxychloroquine, and the Windows of Self-Peptide Presentation in Lupus
A doctor-researcher is studying how flu infection and the lupus medication hydroxychloroquine change the way the immune system shows self-parts to trigger or prevent lupus flares in kids.
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