Early ID and Prevention of Type 1 Diabetes with Genetic Risk Screening and CAR-T-reg Therapy
Official title: Early Identification and Prevention of Type 1 Diabetes Using Polygenic Risk Score Screening and CAR-T-reg Therapy
Funded at Children's Hosp of Philadelphia · NIH-11448535 · Data updated 2026-11-12
A pediatric-focused program aims to identify children at high risk for Type 1 diabetes using genetic risk scores and deliver a novel CAR-T-reg cell therapy to prevent the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 10, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $889,998 |
| NIH project number | 1R01DK145085-01A1 |
| Project ID | NIH-11448535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children identified as high-risk for Type 1 diabetes, based on genetic risk scores and health records.
✕Less likely to help
Children not at high risk or not eligible for the CAR-T-reg therapy may not benefit from this specific intervention.
What this research studies
This project uses a polygenic risk score to flag children who are most likely to develop Type 1 diabetes and combines this with electronic health data from pediatric participants. It plans to test a new cell-based preventive therapy (CAR-T-reg) to interrupt the disease process before symptoms appear. The study involves analyzing genetic data, health records, and safety assessments to build a clinically usable risk-prediction-and-prevention model. If successful, this approach could lead to earlier intervention and possibly reduce the incidence of T1D in children.
Why it matters
Potential benefit: If successful, it could enable earlier, personalized prevention of Type 1 diabetes in at-risk children.
How similar studies have gone: Early genetic-risk screening and targeted therapies are an active area with promising but preliminary results; this project tests a novel CAR-T-reg approach.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Hakonarson, Hakon — Children's Hosp of Philadelphia
- Study coordinator: Hakonarson, Hakon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.