Understanding how bone marrow supports newborn blood formation after illness
Official title: Defining bone marrow factors that support neonatalhematopoiesis
Funded at Children's Hosp of Philadelphia · NIH-11445172 · Data updated 2026-11-12
Researchers will study how newborns’ bone marrow environment changes after severe infections to better protect and rebuild blood formation later in life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $853,295 |
| NIH project number | 1R01DK145431-01A1 |
| Project ID | NIH-11445172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants and young children who have experienced neonatal sepsis or related critical illness, and who are under clinical care at participating sites.
✕Less likely to help
Healthy term or preterm infants without a history of neonatal sepsis may not directly benefit from this research.
What this research studies
This project looks at the cells and signals in the newborn bone marrow that support blood cell formation, especially after sepsis. Using advanced single-cell and metabolic techniques, the team will map how sepsis alters the niche where blood cells are born. The goal is to identify targets that could prevent long-term blood problems such as low blood counts or infections. Findings could guide new treatments or strategies to maintain healthy blood development in affected infants and potentially improve outcomes as they grow.
Why it matters
Potential benefit: If successful, the work could lead to new ways to prevent or reduce long-term blood-related complications in babies who had critical illness.
How similar studies have gone: Previous studies using multimodal genomics and hematopoietic assays have shown promise in understanding bone marrow niches, supporting advancement in this area.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Thom, Christopher Stephen — Children's Hosp of Philadelphia
- Study coordinator: Thom, Christopher Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.