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Clinical trials and research at Case Comprehensive Cancer Center

• 64Clinical trials
• 1Country

Newest trials

All recruiting trials (64)

• Robot-assisted bronchoscopy for peripheral lung lesions: comparing Monarch and ION platforms

  Doctors are testing two FDA-cleared robotic bronchoscopy tools to see which more often successfully sample peripheral lung lesions during a bronchoscopy.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07735611

• Safety and preliminary activity of BMS-986504 in unresectable MPNST

  A new medicine called BMS-986504 is being tested to see if it is safe and may help people with unresectable malignant peripheral nerve sheath tumors, especially those whose tumors lack MTAP.

  Recruiting Phase 1/2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07549022

• Wearable sensors and digital health in early cancer trials

  This pilot study tests whether wearable activity tracking and electronic patient-reported outcomes can be feasibly used in early-phase cancer trials for adults.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07541365

• HPV DNA-guided chemoradiation with Retifanlimab for locally advanced anal cancer

  This study tests whether adjusting chemoradiation doses based on HPV ctDNA results and adding Retifanlimab after CRT can improve outcomes for adults with new, locally advanced anal cancer.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT07425054

• MiraBurst to help with changes in taste from cancer treatment

  This study tests whether freeze-dried miracle fruit (MiraBurst) can improve taste changes in adults with solid tumors who are undergoing cancer treatment.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07419581

• Memory-avoidance whole brain radiotherapy: trying to protect memory while treating brain metastases

  This study tests whether memory-avoidance whole brain radiotherapy with memantine is better at preserving thinking and memory than hippocampal-avoidance whole brain radiotherapy with memantine for adults with brain metastases.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07248228

• Vitamin D and light therapy to boost skin cancer response before surgery

  This study tests whether giving Vitamin D or a placebo around the time of a light-based treatment (PDT) can help boost skin cancer treatment before Mohs surgery or ED&C in adults with basal cell or squamous cell carcinoma.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07241585

• Rituximab and Tafasitamab with Allogeneic NK Cells for relapsed or refractory B-cell NHL

  This trial tests whether giving allogeneic NK cells with Rituximab, Tafasitamab, and IL-2 can help people with relapsed or refractory B-cell non-Hodgkin lymphoma who have tried at least two prior therapies.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT07225439

• Liquid nitrogen spray cryotherapy before chemotherapy for locally advanced esophageal cancer

  This study tests whether adding liquid nitrogen spray cryotherapy to standard chemotherapy helps people with locally advanced esophageal adenocarcinoma reach better treatment response than chemotherapy alone.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Weston, Florida · NCT07222657

• Scrambler Therapy for chemotherapy-related nerve pain (CIPN).

  Researchers will try Scrambler Therapy, a non-drug electrical treatment, to reduce pain and numbness in people with long-lasting chemotherapy-induced peripheral neuropathy.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07219472

• AI-powered support to improve quality of life for people with cancer

  This study will try an AI-powered smartphone app together with regular talk therapy to see if it improves quality of life, anxiety, and depression in adults with stage I–III cancer who are receiving active treatment.

  Recruiting Case Comprehensive Cancer Center · Weston, Florida · NCT07167056

• Remote smartwatch monitoring of walking and daily function in bone cancer

  This study tests whether a smartwatch can track walking stability and daily activities to spot changes during treatment for people with osteosarcoma or metastatic bone disease.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07129226

• Simulation-free celiac plexus SBRT for cancer-related abdominal pain

  This study tests a faster, simulation-free SBRT approach to relieve celiac plexus–related abdominal pain in adults with pancreatic cancer or retroperitoneal pain.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07117032

• Fatty Acid Binding Proteins and Cellular Senescence Markers in Cancer Survivors

  This study tests whether cancer survivors have higher levels of fatty acid binding proteins and cellular senescence markers in their blood compared to people who have never had cancer.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07114614

• Proactive tongue-strengthening after partial/hemiglossectomy with reconstruction

  This program tests whether adding a proactive tongue-strengthening exercise using a Tongueometer biofeedback device helps adults who undergo partial or hemi-glossectomy with reconstruction improve speech and swallowing.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07110142

• Pulmonary rehabilitation for people who survived advanced non-small cell lung cancer

  This research will try an eight-week pulmonary rehabilitation program to see if it helps people with advanced non-small cell lung cancer breathe easier and have more energy.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07104630

• Using AI to help find prostate cancer on MRI

  This study tests whether an AI software can help doctors find suspicious lesions on prostate MRI in men aged 55–80 who are having a pre-biopsy MRI and planned prostate biopsy.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07084779

• Immediate simulation-free SBRT for people with up to five metastatic tumors

  This tests whether giving stereotactic body radiation therapy (SBRT) right away without a separate CT simulation helps people with up to five metastatic cancer spots get treatment faster.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07079098

• Pre-op MRI to predict margins for TORS in HPV-positive tonsil cancer

  This project will test whether a special pre-operative MRI can predict if adults with HPV-positive tonsil cancer will have clear margins after transoral robotic surgery.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07060261

• Histotripsy plus chemotherapy versus chemotherapy alone for colorectal cancer spread to the liver

  This trial will test whether adding noninvasive histotripsy to standard chemotherapy helps people with unresectable, liver‑confined colorectal cancer metastases stay free of disease progression longer.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07044362

• Phase 2 pharmacodynamic test of sitagliptin for progressive grade 4 glioma

  This trial will try sitagliptin in adults with progressive grade 4 glioma to see if it lowers immune-suppressing MDSCs and boosts anti-tumor immune activity before surgery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07003542

• BAFF CAR-T (LMY-920) therapy for relapsed or refractory CLL/SLL

  This trial tests BAFF CAR-T cell therapy (LMY-920) with prior obinutuzumab in adults whose CLL or SLL has relapsed or not responded to prior treatments including BTK and BCL2 inhibitors.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06916767

• Combining an unmodified family (haplo‑identical) donor graft with cord blood for transplant

  This trial will test whether giving an unmodified haplo‑identical donor graft followed by a cord blood graft with post‑transplant cyclophosphamide helps people with high‑risk AML, ALL, or MDS stay free of disease.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06904482

• PSMA PET-guided Lu-177 radioligand therapy for metastatic hepatocellular carcinoma.

  This will test whether Lu-177 PSMA-617 can safely reach and shrink PSMA-positive metastatic hepatocellular carcinoma in adults whose cancer progressed after first-line treatment.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06852820

• Cabazitaxel (with or without carboplatin) versus 177Lu-PSMA-617 for PSMA-positive metastatic castration-resistant prostate cancer

  This trial will try whether cabazitaxel (with or without carboplatin) or the PSMA-targeted radioligand 177Lu-PSMA-617 works better for people with PSMA-positive metastatic castration-resistant prostate cancer who have progressed after hormonal therapy.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06738303

• Detecting Barrett's Esophagus in Patients Without GERD Symptoms

  This study is testing a new way to find Barrett's esophagus in people who don’t have GERD symptoms by using a simple capsule test instead of the usual endoscopy.

  Recruiting at 5 sites Case Comprehensive Cancer Center · Aurora, Colorado and 4 other locations · NCT06687603

• Evaluating vulvovaginal graft-versus-host disease and the vaginal microbiome

  This study is trying to see how changes in the vaginal bacteria of women who have a stem cell transplant might relate to the development of vulvovaginal graft-versus-host disease.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06649201

• Pre-surgery metronidazole and chlorhexidine to lower bacteria in oral cavity tumors

  This study will try a short course of the antibiotic metronidazole plus chlorhexidine mouthwash before surgery to see if it lowers bacteria inside tumors in adults with oral squamous cell carcinoma.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06627270

• Combining Pluvicto with radiation therapy for advanced prostate cancer

  This study is testing if combining the drug Pluvicto with radiation therapy can help people with advanced prostate cancer reduce the chance of their cancer coming back while keeping their quality of life intact.

  Recruiting Phase 1/2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06574880

• Improving cancer care access and outcomes through patient navigation

  This study tests a new way to help people newly diagnosed with cancer get better access to care and support, especially for those who might not have the same resources.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06481774

• Preventing cytokine release syndrome with siltuximab before epcoritamab treatment

  This study is testing if giving siltuximab before treatment with epcoritamab can help prevent serious side effects in people with large B-cell lymphoma or follicular lymphoma.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06447376

• Brain imaging in young patients with acute leukemia

  This study is testing how chemotherapy affects the brains of children and young adults with acute leukemia to see if it causes any thinking problems and to find ways to help them.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06421155

• Fasting during chemotherapy for ovarian cancer

  This study is testing if intermittent fasting during chemotherapy can help improve quality of life and treatment results for people with ovarian cancer compared to regular eating habits.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06386887

• Measuring DNA damage in residents exposed to a train derailment in East Palestine

  This study is trying to see if living near a train derailment in East Palestine has caused DNA damage in local residents by looking at their health and collecting samples like blood and hair.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06357845

• Improving care for Black patients with gastrointestinal cancer

  This study is trying to improve cancer care for Black patients with gastrointestinal cancers by ensuring they get the right tests and treatments while helping us understand the challenges they face.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06263088

• Surgery for Upper Tract Urothelial Carcinoma with or without Lymph Node Removal

  This study is testing whether removing lymph nodes during surgery helps people with upper tract urothelial carcinoma live longer and have fewer cancer recurrences compared to those who don’t have the lymph nodes removed.

  Recruiting at 4 sites Case Comprehensive Cancer Center · Gainesville, Florida and 3 other locations · NCT06262516

• Using Fenofibrate to treat cervical cancer and dysplasia

  This study is testing if Fenofibrate, a cholesterol-lowering drug, can help treat cervical cancer and pre-cancerous changes by trying to improve how cells work and slow down tumor growth.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06191133

• Radiation therapy for metastatic prostate cancer treatment

  This study tests if adding a targeted radiation treatment to standard hormone therapy can help people with newly diagnosed metastatic prostate cancer have better control over their disease.

  Recruiting at 3 sites Phase 2 Case Comprehensive Cancer Center · New York, New York and 2 other locations · NCT06150417

• Daily Partial Breast Irradiation After Repeat Breast Conserving Surgery for Breast Cancer

  This study tests if giving radiation once a day for 15 days after repeat breast surgery can work just as well as the usual twice-a-day treatment for patients with recurring breast cancer.

  Recruiting at 2 sites Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT06129747

• Low-dose decitabine plus venetoclax maintenance after allogeneic stem cell transplant

  This trial tests whether weekly low-dose decitabine followed 6–8 hours later by a venetoclax pill can help prevent relapse after allogeneic stem cell transplant in adults with AML or high‑risk MDS.

  Recruiting at 2 sites Phase 1/2 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT06129734

• Using MRI to Differentiate Between Brain Tumors and Radiation Effects

  This study is testing a new MRI technique to see if it can help tell the difference between brain tumors and radiation damage in people who have had radiation therapy.

  Recruiting at 2 sites Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT06101069

• Using Vactosertib with Chemoradiotherapy for Esophageal Adenocarcinoma

  This study is testing if adding a new drug called vactosertib to standard treatment can help people with localized esophageal adenocarcinoma have better results and lower chances of cancer coming back after surgery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06044311

• Combining targeted therapy with radiation for bladder cancer treatment

  This study is testing if a new targeted treatment combined with radiation can safely help people with muscle-invasive bladder cancer keep their bladders instead of needing surgery.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05833867

• Evaluating the need for drainage after distal pancreatectomy

  This study is testing if patients who have part of their pancreas removed really need drainage tubes afterward, especially when a special stapling method is used, to see if skipping the drainage leads to the same or better recovery.

  Recruiting Phase 3 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05720338

• Educational intervention to help minorities make informed decisions about clinical trials

  This study is testing a new way to help racial and ethnic minority patients feel more informed and confident about joining clinical trials.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05701085

• Comparing single-port robotic prostate surgery to high-intensity focused ultrasound for prostate cancer

  This study is testing whether single-port robotic surgery or high-intensity focused ultrasound is better for treating localized prostate cancer in men with low to intermediate risk.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05610852

• Impact of Mediterranean Diets on Prostate Cancer Metabolism

  This study tests whether following a Mediterranean diet can help men with localized prostate cancer by looking at how it affects their metabolism and overall health.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05590624

• Recording brain activity during surgery for high-grade glioma

  This study is testing if recording brain activity during surgery for high-grade glioma tumors can help us understand how these tumors interact with brain cells to improve treatment options.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05565118

• Tracking weight loss to improve cancer detection

  This study is testing if tracking weight loss in people aged 40 to 80 can help catch cancer earlier using a new blood test.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05481697

• Encouraging prostate cancer screening in Black men

  This study is testing different ways to encourage Black men aged 40 and older to get prostate cancer screenings in local barbershops in Cleveland.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05469269

• Combining disulfiram, copper gluconate, and liposomal doxorubicin for treating relapsed sarcomas

  This study is testing a new treatment that combines disulfiram, copper gluconate, and liposomal doxorubicin to see if it can help people with relapsed sarcomas feel better and live longer.

  Recruiting Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05210374

• Combining Regorafenib and Fulvestrant for Recurrent Low-Grade Serous Ovarian Cancer

  This study is testing if combining the drugs Regorafenib and Fulvestrant can help people with recurrent low-grade serous ovarian cancer by slowing down cancer growth.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05113368

• Using stem cells and chemotherapy to treat brain tumors

  This study is testing a new treatment using stem cells and chemotherapy to see if it can help people with recently removed brain tumors feel better and improve their chances of recovery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT05052957

• Genomic analysis of families with different types of cancer

  This study is testing whether analyzing the DNA of families with a strong history of different types of cancer can help find new gene mutations linked to those cancers.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04860453

• Testing stool samples for cancer detection in colorectal cancer survivors

  This study is testing if a new stool test can help find polyps and cancer in colorectal cancer survivors to see if it works better than regular check-ups.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04624555

• Probiotic BIOHM to change breast tumor and gut microbes

  This trial will test whether taking the probiotic BIOHM can change the bacteria and fungi in the breast tumor and gut of women with breast cancer compared with a placebo.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04362826

• Nicotinamide riboside supplementation to improve stem cell transplant outcomes

  This study is testing if taking nicotinamide riboside can help patients who receive a stem cell transplant recover faster and have fewer complications.

  Recruiting Early Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04332341

• Comparing single and double sessions of spine radiosurgery for vertebral metastases

  This study is testing whether one or two sessions of targeted radiation therapy can better help people with cancer spread to the spine by reducing the risk of fractures and improving their overall well-being.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04218617

• Using 5-Azacitidine and Decitabine to treat myeloid malignancies

  This study is testing a combination of two drugs, 5-azacitidine and decitabine, to see if they can help people with myelodysplastic syndromes and similar blood disorders feel better.

  Recruiting Early Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT04187703

• Using T Cell Therapy to Treat Adenovirus Infection After Stem Cell Transplant

  This study is testing whether using special immune cells from a donor can help treat adenovirus infections in patients who have had a stem cell transplant.

  Recruiting Early Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT03378102

• Using Inotuzumab Ozogamicin after Stem Cell Transplant for Acute Lymphocytic Leukemia

  This study is testing if a new drug called inotuzumab ozogamicin can help people with acute lymphocytic leukemia who have had a stem cell transplant stay healthy and avoid relapse.

  Recruiting at 4 sites Phase 1/2 Case Comprehensive Cancer Center · Westwood, Kansas and 6 other locations · NCT03104491

• Registry of patients treated with proton beam therapy

  This study is creating a database of patients treated with proton beam therapy for cancer to see how well it works and how safe it is.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT02986048

• T Cell Therapy for Cytomegalovirus Infections

  This study is testing whether using special immune cells from donors can help patients who had a stem cell transplant fight off cytomegalovirus infections.

  Recruiting Early Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT02982902

• Neoadjuvant radiosurgery for brain tumors before surgery

  This study is testing if giving radiation treatment before surgery can help prevent brain tumors from coming back in people with brain metastases.

  Recruiting Phase 1/2 Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT01891318

Quick answers

How many clinical trials run by Case Comprehensive Cancer Center are recruiting right now?

64, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 15, Phase 1: 9, Phase 1/2: 5, Early Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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