Measuring DNA damage in residents exposed to a train derailment in East Palestine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the biological impact of chemical exposure resulting from a train derailment in East Palestine, Ohio, by measuring somatic mutation rates in residents. Participants will complete surveys regarding their health experiences and may provide biological specimens such as blood and hair for analysis. The research will explore the relationship between DNA damage and factors like proximity to the derailment and individual health histories. The study seeks to establish a cohort for ongoing research into the long-term health effects of environmental exposure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Residence on February 3rd, 2023 in Columbiana County, Ohio, Mahoning County, Ohio, Beaver County, PA, or Lawrence County, PA.
* Current residence in the United States.

Exclusion Criteria:

* Address provided for February 3rd, 2023 not in Columbiana County, Ohio, Mahoning County, Ohio, Beaver County, PA, or Lawrence County, PA
* Invalid address provided for February 3rd, 2023 residence.

Where it's running

• Case Western Reserve University, Case Comprehensive Cancer Center
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Fredrick R Schumacher, PhD — Case Western Reserve University, Case Comprehensive Cancer Center
• Study coordinator: Fredrick R Schumacher, PhD
• Email: healthyfutures@case.edu
• Phone: 216-368-0351

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exploring genetic differences in twins with childhood brain tumors

  This study looks at the genetic differences in identical twins who have childhood brain tumors to see how these differences might affect their cancer.

  Recruiting Children's Oncology Group · Minneapolis, Minnesota · NCT06054295

• T cell receptor depletion for blood cancer treatment

  This study is testing a new way to treat blood cancers by using a special treatment before a stem cell transplant to see if it helps both kids and adults do better after the procedure.

  Recruiting Phase 2 Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT05735717

• Identifying genes in systemic autoinflammatory diseases

  This study is trying to find new genes linked to rare autoinflammatory diseases to help doctors diagnose and treat patients better.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT05364294

• Evaluating EGFR-TKI treatments in lung cancer patients

  This study is testing how well different EGFR-TKI treatments work for people with advanced lung cancer and looking at how genetic factors and drug levels affect their results.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT01994057

• Postoperative Rectal Pain Relief With Ear Vagus Nerve Stimulation

  This study tests whether stimulating the vagus nerve through an ear-based device can reduce pain after anal or rectal surgery.

  Recruiting University Hospital, Angers · Angers, Maine et Loire · NCT07659314

• Virtual approaches for period pain in young women

  This study tests two online self-care options—auricular acupressure and Baduanjin qigong—against a self-care education group to see if they reduce menstrual pain and related symptoms in young women.

  Recruiting Phase 2/3 Nanyang Technological University · Singapore · NCT07497711

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.