Fatty Acid Binding Proteins and Cellular Senescence Markers in Cancer Survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure Fatty Acid Binding Proteins (FABP4 and FABP5) and 12 markers of cellular senescence in blood samples from cancer survivors who completed treatment at least 2 years ago, and compare them to individuals without a cancer history. Researchers will examine how these biomarker levels relate to the type of cancer therapies received and to the development of metabolic conditions such as obesity, hypertension, and diabetes. The study aims to identify correlations between biomarker profiles and prior treatments, as well as potential metabolic risks in survivors. Pediatric and young adult survivor populations are highlighted due to unique long-term health risks following cancer therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of at least one malignancy for which chemotherapy, radiation, and/or stem cell transplantation was utilized as part of treatment
* Completed all therapeutic interventions for their malignancy and are at least 2 years off therapy
* At least 1-year post-stem cell transplant for malignant condition

Exclusion Criteria:

1. Pregnancy at the time of the study
2. Any autoimmune condition including but not limited to lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis, type 1 diabetes, EXCEPT well-controlled autoimmune hypothyroidism for at least 6 months
3. Presence of active graft versus host disease
4. Malignancy treated using surgery only
5. Acute relapsed disease or second malignancy
6. Transplant for non-malignant conditions (e.g. cell disease, Hurler syndrome)
7. Currently taking systemic steroids and/or immunosuppressant medications
8. Acute illness necessitating hospitalization in the 30 days prior to blood draw
9. Presence of a chronic inflammatory disease EXCEPT obesity
10. Fever, active infection or inflammation, or taking antibiotics at the time of blood draw
11. A diagnosis of Type 2 diabetes or Hypertension treated with medication
12. Currently lipid lowering medications
13. Growth hormone deficiency or hypothalamic dysfunction

Where it's running

• Case Comprehensive Cancer Center, UH Rainbow Babies & Children's Hospital
  Cleveland, Ohio, United States Recruiting

Study contacts

• Study coordinator: Hackney Lisa, MD
• Email: Lisa.hackney@uhhospitals.org
• Phone: 216-541-1088

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.