Sponsor or institution
Clinical trials and research at Buck Institute for Research on Aging
As of November 12, 2026, Find a Trial lists 4 clinical trials run by Buck Institute for Research on Aging that are recruiting, in United States. There are also 61 NIH-funded research projects at this institution, with $41.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 61NIH research projects
- 1Country
Newest trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Mapping body rhythms over time in older adults | — | Novato, California | Recruiting | Aug 6, 2025 |
| GLYLO supplement to lower glycation and support healthy aging in postmenopausal women | — | Novato, California | Recruiting | Feb 6, 2025 |
| Ketone supplement to improve strength and wellbeing in older adults with mild frailty | — | Novato, California and 2 other locations | Recruiting | Oct 17, 2024 |
| Investigating muscle and health characteristics in older adults and elite athletes | — | Novato, California | Recruiting | Aug 6, 2024 |
All recruiting trials (4)
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Mapping body rhythms over time in older adults
This project will see how daily and weekly biological changes—from blood, urine, and wearable devices—track in healthy adults aged 55 and older.
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GLYLO supplement to lower glycation and support healthy aging in postmenopausal women
This study tests whether taking GLYLO capsules for 24 weeks can lower harmful advanced glycation end products (AGEs) and improve metabolic and hormonal health in overweight or obese postmenopausal women aged 45–65 with mildly elevated HbA1c.
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Ketone supplement to improve strength and wellbeing in older adults with mild frailty
This study tests whether taking a daily ketone ester supplement for 20 weeks can help people aged 65 and older with slight declines in physical function become stronger and feel healthier.
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Investigating muscle and health characteristics in older adults and elite athletes
This study looks at how muscle and health traits differ between healthy older adults and elite athletes aged 65-80 to see how physical activity affects aging.
NIH-funded research (newest 40 of 61)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Mapping and validating senescent cells in human tissues to guide healthier aging
Aims to map and validate senescent cells in human tissues and identify biomarkers to monitor how senolytic treatments affect aging tissues.
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Diet, mating, and aging: how reproduction and eating shape aging in humans and flies
Aging and healthspan may be influenced by how diet and reproductive timing interact, and this project will explore that connection in humans and fruit flies.
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How nerves affect muscle stem cells as we age
A patient-friendly look at a study exploring how the nervous system's signals influence aging muscle stem cells and muscle mass in adults.
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How the brain's fuel signals relate to Alzheimer's and aging
A researcher is studying how ketone signals like beta-hydroxybutyrate affect aging brains and Alzheimer’s disease, with the goal of finding new ways to support brain health.
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Understanding how the ovarian aging process affects women’s health through the lymphatic system
A small NIH grant aims to uncover how aging ovaries interact with the body’s lymphatic system to slow reproductive aging and impact overall health in women.
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KIBRA-based peptide to repair synapses and improve memory in tau-related dementia
A study in mouse models of Alzheimer's-like tauopathy tests a KIBRA-derived peptide to repair brain connections and improve memory related to dementia.
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How aging brain cells and their interactions drive Alzheimer's and related dementias
Researchers are looking at how aging brain cells and their neighbors lead to Alzheimer's and other age-related dementias to help find new ways to prevent or treat memory and thinking problems.
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Mitochondria-lysosome crosstalk and aging
This NIH grant investigates how the communication between mitochondria and lysosomes changes with age and how that affects cellular health.
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How diet and aging affect eye cell health and vision
Aging and diet may shape how our eye cells stay healthy and keep people seeing clearly as they age.
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Protecting the striatal neurons that fail in Huntington's disease
This project looks at whether correcting early developmental problems in the striatal brain cells affected by Huntington's disease can be reversed using patient-derived stem cells and repurposed drugs.
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How targeted cell cleanup (selective autophagy) affects aging and health
Researchers are looking at whether boosting selective autophagy — the cell's targeted cleanup of damaged proteins and mitochondria — can help improve health as organisms age.
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Identifying organ blood biomarkers of aging and their effects on heart health
A research project aims to find blood-based signs of aging in different organs and understand how they influence heart health.
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How brain stem cells stay dormant and healthy as we age
This project looks at why the brain’s stem cells stop making new neurons with age and seeks ways to keep them healthy for people with age-related memory problems like Alzheimer’s.
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Aging immune cells and lysosome problems
Researchers are learning how older immune cells and faulty cell 'recycling centers' (lysosomes) drive chronic inflammation so future treatments can reduce age-related damage.
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Mitochondria's role in insulin release for people with type 2 diabetes
This project looks at whether restoring a mitochondrial energy step called succinate dehydrogenase can help insulin-producing beta cells respond to glucose in people with type 2 diabetes.
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How insulin changes B immune cells in obesity and type 2 diabetes
This project looks at how insulin changes B cells in people with obesity to better understand why insulin stops working and can lead to type 2 diabetes.
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Finding aging (senescent) cells in muscle, ovaries, and breast tissue
This project looks for specific signs of aging cells in muscle, ovaries, and breast tissue from people of different ages to better understand how aging changes those tissues.
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Using AI and lab tests to predict harmful aging cells in people
We use advanced laboratory measurements and artificial intelligence to estimate how many senescent (aging) cells are present across different tissues in people.
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Collecting human tissues and fluids to map aging cells
Researchers are collecting donated tissues, blood, and urine from consenting adults to map where and how aging (senescent) cells build up in ovary, breast, and muscle.
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Maps of aging cells and their signals in ovaries, breast, and muscle
Researchers are creating detailed maps of aging cells and the signals they release in ovaries, breast tissue, and skeletal muscle to help people affected by tissue aging.
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Ketone ester to improve function in frail older adults
Seeing if a ketone supplement can boost energy and physical function in older adults living with frailty.
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How mRNA modifications affect nerve cell communication
This study is looking at how a special change in a type of genetic material affects the way nerve cells communicate with each other, using fruit flies to help understand what happens when this change doesn't work properly, which could give us clues about both healthy brains and those with problems.
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Training course focused on aging research
This friendly training course is designed for early-career researchers interested in aging, offering them a chance to learn about the latest in geroscience and get personalized help with their research ideas over five days each year from 2025 to 2029.
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Understanding how cell parts communicate to slow aging
This research explores how tiny parts within our cells, called mitochondria and lysosomes, talk to each other, and how this communication changes as we get older.
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How abnormal tau protein disrupts tiny protein factories in brain connections that support memory
This project looks at whether abnormal tau protein stops local protein production in nerve cell branches, which may help explain memory loss in people with Alzheimer’s disease and related dementias.
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Smart cell delivery to target and control combination treatments for Alzheimer's
A team is developing a living cell system to carry and release combinations of Alzheimer's medicines directly where they're needed for people with Alzheimer's disease.
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Understanding how diet and aging affect vision and eye health
This research explores how what we eat and how we age influence our eyesight and the health of our eyes.
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Finding blood markers that show how aging affects heart health
This study is looking at how getting older affects heart health by checking certain blood markers and how different organs age together, so we can better understand heart problems and find ways to help.
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Understanding how Alzheimer's Disease affects neural stem cells
This study is looking at how Alzheimer's Disease affects special brain cells that help with memory and mood, using both mice and human samples to find out what changes happen in these cells, which could help us discover new treatments for the disease.
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Advanced imaging technology for studying molecular changes in aging and Alzheimer's disease
This study is exploring a new technology that helps scientists see and understand the tiny changes in tissues related to age-related diseases like Alzheimer's, so they can learn more about how these conditions develop and progress.
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Understanding how aging cells contribute to Alzheimer's disease
This work explores how aging cells in the brain might cause Alzheimer's disease and related dementias, looking for new ways to slow or stop these conditions.
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Understanding Aging, NAD+ Levels, and Alzheimer's Disease
This research explores how changes in the body's energy (NAD+) and aging cells might contribute to Alzheimer's disease and related dementias.
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Understanding how aging cells contribute to Alzheimer's and related dementias
This project explores how aging cells in the brain might cause Alzheimer's and other memory problems.
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Understanding Alzheimer's Disease Through Individual Cell Analysis
This core aims to understand how aging contributes to Alzheimer's disease by looking closely at individual brain cells.
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Understanding Cell Aging in Alzheimer's and Related Dementias
This research explores how aging cells and their interactions in the brain contribute to Alzheimer's disease and other forms of dementia.
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Investigating how certain metabolites affect inflammation and energy failure in older adults with delirium
This study is looking at how brain inflammation and energy problems might lead to confusion in older adults with Alzheimer's and similar conditions, and it’s exploring whether using ketone bodies can help boost brain energy and improve thinking skills to reduce confusion.
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Understanding how neuropeptides affect brain circuits and behavior
This study is looking at how special brain chemicals called neuropeptides affect behaviors related to energy, mood, and stress, using techniques on animals like worms and mice, to help us understand issues like obesity and mental health conditions.
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Investigating how certain proteins affect aging and brain health
This study is looking at how certain proteins called FOXO might help us understand aging and diseases like Alzheimer's, with the hope of finding ways to keep our brains healthy as we get older.
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How selective autophagy affects health as we age
This study is looking at how a process called selective autophagy, which helps keep our cells healthy, might improve our health as we get older, especially by focusing on a protein called p62, and it aims to share helpful insights for patients about staying healthy in their later years.
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Investigating how proteins in bones change during osteoarthritis
This study is looking at how osteoarthritis affects the proteins in your bones and cartilage, using special technology to help doctors find better ways to track the disease and improve treatments for people with joint pain.
Quick answers
How many clinical trials run by Buck Institute for Research on Aging are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.