Investigating how certain metabolites affect inflammation and energy failure in older adults with delirium
Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium
This study is looking at how brain inflammation and energy problems might lead to confusion in older adults with Alzheimer's and similar conditions, and it’s exploring whether using ketone bodies can help boost brain energy and improve thinking skills to reduce confusion.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-11098994 on NIH RePORTER |
What this research studies
This research focuses on understanding delirium, a common condition in older adults characterized by confusion, particularly in those with Alzheimer's Disease and Related Dementias (ADRD). The study aims to explore the connection between neuroinflammation and energy disruption in the brain, using various methods including cell systems, mouse models, and human biospecimens. By examining how ketone bodies can serve as an alternative energy source for the brain, the research seeks to uncover potential therapeutic strategies to improve cognitive function and reduce the risk of delirium in older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, especially those diagnosed with Alzheimer's Disease or related dementias who are at risk for delirium.
Not a fit: Patients who are younger or do not have any cognitive impairments or risk factors for delirium may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent or alleviate delirium in older adults, particularly those with Alzheimer's Disease.
How similar studies have performed: Previous research has shown promising results using ketogenic diets to improve cognitive function in aging models, suggesting potential success for this approach.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Newman, John C — Buck Institute for Research on Aging
- Study coordinator: Newman, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.