How mRNA modifications affect nerve cell communication
Official title: Regulation of synaptic activity by mRNA methylation
Funded at Buck Institute for Research on Aging · NIH-11168256 · Data updated 2026-11-12
This study is looking at how a special change in a type of genetic material affects the way nerve cells communicate with each other, using fruit flies to help understand what happens when this change doesn't work properly, which could give us clues about both healthy brains and those with problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $676,789 |
| NIH project number | 1R56NS135053-01A1 |
| Project ID | NIH-11168256 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodegenerative disorders or those with conditions that impact synaptic function.
✕Less likely to help
Patients with acute injuries or conditions unrelated to synaptic dysfunction may not benefit from this research.
What this research studies
This research investigates the role of a specific mRNA modification, known as N6-methyladenosine (m6A), in regulating neurotransmitter release at synapses, which are critical for nerve cell communication. Using Drosophila (fruit flies) as a model organism, the researchers will explore how mutations in m6A factors impact normal synaptic function. The study aims to uncover new mechanisms of m6A regulation and its effects on neuronal activity, providing insights into both healthy and diseased states of the nervous system.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative disorders by enhancing our understanding of synaptic regulation.
How similar studies have gone: Previous research has shown promising results in understanding mRNA modifications and their impact on neuronal function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Haghighi, Ali Pejmun — Buck Institute for Research on Aging
- Study coordinator: Haghighi, Ali Pejmun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.