Understanding Alzheimer's Disease Through Individual Cell Analysis
Single cell analysis core
['FUNDING_P01'] · BUCK INSTITUTE FOR RESEARCH ON AGING · NIH-11099704
This core aims to understand how aging contributes to Alzheimer's disease by looking closely at individual brain cells.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BUCK INSTITUTE FOR RESEARCH ON AGING (nih funded) |
| Locations | 1 site (NOVATO, UNITED STATES) |
| Trial ID | NIH-11099704 on ClinicalTrials.gov |
What this research studies
Alzheimer's disease is a challenging condition with no effective treatments, and aging is the biggest risk factor. This work focuses on a new way to understand how aging might cause nerve cell damage in Alzheimer's by studying tiny populations of 'senescent' cells, which are cells that have stopped dividing and can cause harm. By looking at individual cells, we can find these rare cells that might be missed with older methods. This helps us learn more about how these cells change in the brain and contribute to the disease.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but its findings could eventually benefit individuals living with Alzheimer's disease.
Not a fit: Patients seeking immediate new treatments or direct clinical participation will not find direct benefit from this specific core's activities.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease, potentially identifying new targets for future treatments.
How similar studies have performed: Single-cell analysis is a cutting-edge technique that has already revealed important insights in various diseases, making this a promising approach for Alzheimer's.
Where this research is happening
NOVATO, UNITED STATES
- BUCK INSTITUTE FOR RESEARCH ON AGING — NOVATO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELOV, SIMON — BUCK INSTITUTE FOR RESEARCH ON AGING
- Study coordinator: MELOV, SIMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease