Understanding Alzheimer's Disease Through Individual Cell Analysis
Official title: Single cell analysis core
Funded at Buck Institute for Research on Aging · NIH-11099704 · Data updated 2026-11-12
This core aims to understand how aging contributes to Alzheimer's disease by looking closely at individual brain cells.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 30, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $285,180 |
| NIH project number | 5P01AG066591-05 |
| Project ID | NIH-11099704 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients, but its findings could eventually benefit individuals living with Alzheimer's disease.
✕Less likely to help
Patients seeking immediate new treatments or direct clinical participation will not find direct benefit from this specific core's activities.
What this research studies
Alzheimer's disease is a challenging condition with no effective treatments, and aging is the biggest risk factor. This work focuses on a new way to understand how aging might cause nerve cell damage in Alzheimer's by studying tiny populations of 'senescent' cells, which are cells that have stopped dividing and can cause harm. By looking at individual cells, we can find these rare cells that might be missed with older methods. This helps us learn more about how these cells change in the brain and contribute to the disease.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease, potentially identifying new targets for future treatments.
How similar studies have gone: Single-cell analysis is a cutting-edge technique that has already revealed important insights in various diseases, making this a promising approach for Alzheimer's.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Melov, Simon — Buck Institute for Research on Aging
- Study coordinator: Melov, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.