Investigating how proteins in bones change during osteoarthritis
Official title: Spatial Proteomics of osteoarthritis in bones to uncover disease progression
Funded at Buck Institute for Research on Aging · NIH-11073531 · Data updated 2026-11-12
This study is looking at how osteoarthritis affects the proteins in your bones and cartilage, using special technology to help doctors find better ways to track the disease and improve treatments for people with joint pain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $456,808 |
| NIH project number | 1R21AR084303-01A1 |
| Project ID | NIH-11073531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with osteoarthritis or those experiencing meniscal injuries.
✕Less likely to help
Patients with conditions unrelated to osteoarthritis or musculoskeletal injuries may not benefit from this research.
What this research studies
This research focuses on understanding the molecular changes that occur in bones and cartilage during osteoarthritis and related injuries. Using advanced Mass Spectrometry Imaging (MSI) technologies, the team aims to visualize and analyze proteins in the extracellular matrix of joints. By examining these molecular details, the research seeks to develop new assays that can monitor disease progression and assess the effectiveness of treatments. The study involves a collaborative effort from experts in proteomics and orthopedics to create innovative tools for better understanding and managing osteoarthritis.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with osteoarthritis.
How similar studies have gone: Previous research has shown promise in using proteomic approaches to study osteoarthritis, indicating potential for success in this innovative methodology.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Schilling, Birgit — Buck Institute for Research on Aging
- Study coordinator: Schilling, Birgit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.