Investigating how proteins in bones change during osteoarthritis
Spatial Proteomics of osteoarthritis in bones to uncover disease progression
This study is looking at how osteoarthritis affects the proteins in your bones and cartilage, using special technology to help doctors find better ways to track the disease and improve treatments for people with joint pain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-11073531 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular changes that occur in bones and cartilage during osteoarthritis and related injuries. Using advanced Mass Spectrometry Imaging (MSI) technologies, the team aims to visualize and analyze proteins in the extracellular matrix of joints. By examining these molecular details, the research seeks to develop new assays that can monitor disease progression and assess the effectiveness of treatments. The study involves a collaborative effort from experts in proteomics and orthopedics to create innovative tools for better understanding and managing osteoarthritis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with osteoarthritis or those experiencing meniscal injuries.
Not a fit: Patients with conditions unrelated to osteoarthritis or musculoskeletal injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with osteoarthritis.
How similar studies have performed: Previous research has shown promise in using proteomic approaches to study osteoarthritis, indicating potential for success in this innovative methodology.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Schilling, Birgit — Buck Institute for Research on Aging
- Study coordinator: Schilling, Birgit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.