Advanced imaging technology for studying molecular changes in aging and Alzheimer's disease
Official title: timsTOF fleX MALDI-2 for Spatial Molecular Imaging
Funded at Buck Institute for Research on Aging · NIH-11102926 · Data updated 2026-11-12
This study is exploring a new technology that helps scientists see and understand the tiny changes in tissues related to age-related diseases like Alzheimer's, so they can learn more about how these conditions develop and progress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,759,412 |
| NIH project number | 1S10OD038264-01 |
| Project ID | NIH-11102926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or other age-related disorders.
✕Less likely to help
Patients with non-age-related conditions or those not affected by Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on acquiring a cutting-edge mass spectrometry platform that allows scientists to visualize and analyze molecular signatures in human and animal tissues. By using this technology, researchers can monitor various biological molecules, including proteins, lipids, and metabolites, with high spatial resolution. This approach aims to enhance our understanding of age-related diseases, particularly Alzheimer's, by providing detailed insights into the molecular changes occurring in tissues. The research will involve collaboration among multiple principal investigators, leveraging their collective expertise and NIH-funded projects.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating age-related diseases like Alzheimer's by revealing critical molecular insights.
How similar studies have gone: Previous research using advanced mass spectrometry techniques has shown promise in understanding complex biological systems, indicating potential success for this novel approach.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Schilling, Birgit — Buck Institute for Research on Aging
- Study coordinator: Schilling, Birgit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.