Mitochondria-lysosome crosstalk and aging
Official title: Novel mitochondria-to-lysosome crosstalk contributes to lysosomal dysfunction during aging
Funded at Buck Institute for Research on Aging · NIH-11367483 · Data updated 2026-11-12
This NIH grant investigates how the communication between mitochondria and lysosomes changes with age and how that affects cellular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $485,000 |
| NIH project number | 5R01AG082824-04 |
| Project ID | NIH-11367483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults or older individuals interested in participating in aging-related research through future clinical translation or related studies; specific eligibility will be defined by future trials.
✕Less likely to help
This grant does not involve a current patient directly; benefits would come from future translational research and therapies.
What this research studies
As a patient, you might be affected by aging-related cellular changes that disrupt how parts of cells talk to each other. The project studies how mitochondria and lysosomes interact and how their communication deteriorates over time, contributing to aging. It uses models like C. elegans and human cells to explore this crosstalk and its impact on proteostasis and organelle function. Findings could reveal new angles for therapies that support cellular health during aging.
Why it matters
Potential benefit: Understanding this crosstalk could lead to strategies that preserve cellular health and potentially delay age-related deterioration.
How similar studies have gone: Previous work shows mitochondria-lysosome interactions influence aging processes, suggesting this approach could yield meaningful insights.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Zhou, Chuankai — Buck Institute for Research on Aging
- Study coordinator: Zhou, Chuankai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.