Understanding Cell Aging in Alzheimer's and Related Dementias
Official title: Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias
Funded at Buck Institute for Research on Aging · NIH-11099695 · Data updated 2026-11-12
This research explores how aging cells and their interactions in the brain contribute to Alzheimer's disease and other forms of dementia.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 30, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $2,808,473 |
| NIH project number | 5P01AG066591-05 |
| Project ID | NIH-11099695 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for anyone interested in the underlying causes of Alzheimer's disease and related dementias, as it seeks to understand the basic biological processes involved.
✕Less likely to help
Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this early-stage biological investigation.
What this research studies
We know that aging is the biggest factor in developing Alzheimer's and similar memory conditions, yet effective treatments are still missing. This project aims to uncover new ways to understand and treat these age-related brain changes. It focuses on three key areas: how brain cells decide their fate (like cell death or aging), how they process energy, and how different brain cells communicate with each other. By looking closely at these processes, we hope to find new targets for therapies.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that delay or even reverse the progression of Alzheimer's disease and other age-related dementias.
How similar studies have gone: While the specific combination of approaches may be novel, individual components like studying cellular senescence and metabolic changes have shown promise in other age-related disease contexts.
Where this research is happening
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Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Ellerby, Lisa M — Buck Institute for Research on Aging
- Study coordinator: Ellerby, Lisa M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.