Understanding how Alzheimer's Disease affects neural stem cells
Official title: Investigation of impaired neural stem cell activation in Alzheimer's Disease
Funded at Buck Institute for Research on Aging · NIH-11105843 · Data updated 2026-11-12
This study is looking at how Alzheimer's Disease affects special brain cells that help with memory and mood, using both mice and human samples to find out what changes happen in these cells, which could help us discover new treatments for the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $472,287 |
| NIH project number | 5R01AG076933-04 |
| Project ID | NIH-11105843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who are experiencing symptoms of Alzheimer's Disease or are at risk for developing it.
✕Less likely to help
Patients with early-stage Alzheimer's Disease or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the impact of Alzheimer's Disease (AD) on neural stem cells in the brain, particularly focusing on how these cells, which are crucial for memory and mood regulation, become impaired. By using a combination of advanced techniques, including transcriptomics and metabolomics, the study aims to uncover the molecular changes that occur in these cells during AD. The research utilizes both mouse models and human tissue to provide a comprehensive understanding of the disease's effects on neurogenesis. Patients may benefit from insights gained that could lead to new therapeutic strategies for AD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance neurogenesis and improve cognitive function in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in understanding neurogenesis in other neurodegenerative diseases, suggesting that this approach may yield valuable insights for Alzheimer's Disease as well.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Webb, Ashley E — Buck Institute for Research on Aging
- Study coordinator: Webb, Ashley E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.