Mapping body rhythms over time in older adults
An Observational, Longitudinal Study to Characterize the Dynamic Structure of Molecular and Digital Health Data in Healthy Older Adults
This project will see how daily and weekly biological changes—from blood, urine, and wearable devices—track in healthy adults aged 55 and older.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | Buck Institute for Research on Aging Academic / other |
| Locations | 1 site (Novato, California) |
| Trial ID | NCT07107386 on ClinicalTrials.gov |
What this trial studies
The TIME project follows healthy adults aged 55+ with weekly in-person visits over 11 weeks to collect blood, urine, and other biological samples. Participants wear health-tracking devices (such as a smart ring and smartwatch) and use smartphone apps so researchers can collect continuous physiological and behavioral data. Researchers will integrate molecular measurements with wearable and activity data to map short-term (daily and weekly) rhythms across multiple body systems. The goal is to better understand normal aging-related patterns and provide a foundation for more personalized timing of care and diagnostics.
Who should consider this trial
Good fit: Healthy adults age 55 or older who live in the Pacific or Mountain Time zones, own a compatible smartphone, can speak English, and can travel to the Buck Institute in Novato, CA for weekly visits are ideal candidates.
Not a fit: People with recent hospitalization, unstable or serious chronic conditions, those on excluded medications or frequent antibiotics, night or irregular shift workers, non-English speakers, or those unable to attend weekly visits are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the findings could enable more personalized healthcare by timing treatments and monitoring to an individual's natural biological rhythms.
How similar studies have performed: Previous chronobiology and wearable-device studies have produced useful insights into daily rhythms, but this dense, multimodal weekly sampling approach in older adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adults aged 55 years or older. * Own a smartphone capable of running study-specific apps. * Willing and able to attend in-person visits at the Buck Institute in Novato, CA. * Reside in the Pacific or Mountain Time Zones. * Able to speak, read, and write English. * Willing to wear study devices continuously and allow researchers access to all data. * Able to provide informed consent. Exclusion Criteria: * Hospitalization within the last 3 months. * Needing assistance with daily living activities. * Working night or irregular shifts. * Certain musculoskeletal, pulmonary, or cardiovascular conditions. * Uncontrolled high blood pressure (BP \> 180/100 mmHg). * Bleeding disorders, anemia requiring treatment, or recent blood donation. * Poor vein access. * Unstable health conditions. * Chronic antibiotic use. * Certain psychiatric disorders. * Use of excluded medications, supplements, or products, including certain antibiotics or frequent sleep aids.
Where this trial is running
Novato, California
- Buck Institute — Novato, California, United States (Recruiting)
Study contacts
- Principal investigator: James Yurkovich, PhD — Phenome Health, The Buck Institute for Research on Aging
- Study coordinator: Brianna Stubbs, Research Assistant Professor, PhD.
- Email: TIME-Study@buckinstitute.org
- Phone: (415) 209-2072
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.