Mapping body rhythms over time in older adults
Official title: An Observational, Longitudinal Study to Characterize the Dynamic Structure of Molecular and Digital Health Data in Healthy Older Adults
Run by Buck Institute for Research on Aging · NCT07107386 · Data updated 2026-11-12
This project will see how daily and weekly biological changes—from blood, urine, and wearable devices—track in healthy adults aged 55 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 55 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Buck Institute for Research on Aging Academic / other |
| Locations | 1 site (Novato, California) |
| Status | Recruiting |
| Started | June 15, 2025 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | August 15, 2025 |
| Trial ID | NCT07107386 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults age 55 or older who live in the Pacific or Mountain Time zones, own a compatible smartphone, can speak English, and can travel to the Buck Institute in Novato, CA for weekly visits are ideal candidates.
✕Probably not a fit
People with recent hospitalization, unstable or serious chronic conditions, those on excluded medications or frequent antibiotics, night or irregular shift workers, non-English speakers, or those unable to attend weekly visits are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The TIME project follows healthy adults aged 55+ with weekly in-person visits over 11 weeks to collect blood, urine, and other biological samples. Participants wear health-tracking devices (such as a smart ring and smartwatch) and use smartphone apps so researchers can collect continuous physiological and behavioral data. Researchers will integrate molecular measurements with wearable and activity data to map short-term (daily and weekly) rhythms across multiple body systems. The goal is to better understand normal aging-related patterns and provide a foundation for more personalized timing of care and diagnostics.
Why it matters
Potential benefit: If successful, the findings could enable more personalized healthcare by timing treatments and monitoring to an individual's natural biological rhythms.
How similar studies have gone: Previous chronobiology and wearable-device studies have produced useful insights into daily rhythms, but this dense, multimodal weekly sampling approach in older adults is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adults aged 55 years or older. * Own a smartphone capable of running study-specific apps. * Willing and able to attend in-person visits at the Buck Institute in Novato, CA. * Reside in the Pacific or Mountain Time Zones. * Able to speak, read, and write English. * Willing to wear study devices continuously and allow researchers access to all data. * Able to provide informed consent. Exclusion Criteria: * Hospitalization within the last 3 months. * Needing assistance with daily living activities. * Working night or irregular shifts. * Certain musculoskeletal, pulmonary, or cardiovascular conditions. * Uncontrolled high blood pressure (BP \> 180/100 mmHg). * Bleeding disorders, anemia requiring treatment, or recent blood donation. * Poor vein access. * Unstable health conditions. * Chronic antibiotic use. * Certain psychiatric disorders. * Use of excluded medications, supplements, or products, including certain antibiotics or frequent sleep aids.
Where it's running
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Buck Institute
Novato, California, United States Recruiting
Study contacts
- Principal investigator: James Yurkovich, PhD — Phenome Health, The Buck Institute for Research on Aging
- Study coordinator: Brianna Stubbs, Research Assistant Professor, PhD.
- Email: TIME-Study@buckinstitute.org
- Phone: (415) 209-2072
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.