Understanding hip fractures in patients with chronic kidney disease
Official title: Hip Fracture Pathology in Chronic Kidney Disease
Funded at University of California, San Diego · NIH-10768615 · Data updated 2026-11-12
This study is looking at the special challenges faced by people with chronic kidney disease who have hip fractures, to better understand their bone health and help doctors find the best treatments for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $627,954 |
| NIH project number | 5R01AG065876-05 |
| Project ID | NIH-10768615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults with chronic kidney disease who are at risk for hip fractures.
✕Less likely to help
Patients without chronic kidney disease or those who do not have a risk of hip fractures may not benefit from this research.
What this research studies
This research investigates the unique challenges faced by patients with chronic kidney disease (CKD) who experience hip fractures. It aims to understand the different types of bone diseases present in CKD patients, which can complicate treatment options. By utilizing advanced techniques like bone biopsy and histomorphometry, the study seeks to determine bone turnover rates in these patients. The ultimate goal is to provide insights that can help clinicians choose the most effective treatments to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better treatment strategies for hip fractures in patients with chronic kidney disease, potentially reducing morbidity and mortality.
How similar studies have gone: While the approach of studying bone turnover in CKD patients is gaining attention, this specific investigation into hip fractures and their treatment remains relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hughes-Austin, Jan Marie — University of California, San Diego
- Study coordinator: Hughes-Austin, Jan Marie
Related research
Other NIH-funded projects on the same topics.
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Hip fracture risk in people with chronic kidney disease
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
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Therapeutic use of 3D-printed scaffolds and small-molecule activators to heal bone fractures in CKD mice
A bone-healing strategy using 3D-printed scaffolds and two small molecules aims to improve fracture healing in a mouse model of chronic kidney disease.
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Personalized CKD-MBD care using systems biology and AI
A patient-facing program aims to tailor mineral-balance therapy for people with chronic kidney disease by using a computer model and smart decision rules to predict who will respond best to treatments.
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Mitigating DKA in people with type 1 diabetes and kidney disease using SGLT1/2 inhibitors
This project tests a new way to prevent dangerous diabetic ketoacidosis in people with type 1 diabetes and chronic kidney disease who are using SGLT inhibitors, by tracking ketones in real time and combining glucose-keton data for safer therapy.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.