Condition

Tendinopathy clinical trials and research

• 11Clinical trials
• 21NIH research projects
• 8Countries

Newest Tendinopathy clinical trials

All recruiting trials (11)

• Hyaluronic Acid vs Platelet-R-rich Plasma for Chronic Tendinopathy and Enthesopathy

  This study tests whether injections of hyaluronic acid or autologous platelet-rich plasma can help people with chronic tendon and enthesis problems in the elbow or Achilles area.

  Recruiting Ortonika Orthopedic Medical Clinic in Lublin · Lublin, Lublin Voivodeship · NCT07714811

• Vibration or cool-spray to reduce pain from steroid injections in the hand and wrist

  This trial tests whether vibration or vapocoolant spray makes corticosteroid injections in the hands, wrists, or elbows less painful for adults with arthritis, tendinopathy, or nerve compression.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07553273

• Percutaneous electrolysis versus laser for supraspinatus tendon pain

  This study will test whether percutaneous electrolysis or laser therapy better reduces pain and improves shoulder function in adults with supraspinatus tendinopathy.

  Recruiting Universidad Pontificia de Salamanca · Salamanca · NCT07247825

• Platelet-rich plasma injections for joint and tendon problems

  This project will test whether platelet-rich plasma (PRP) injections help people with osteoarthritis and other musculoskeletal conditions reduce pain and improve function over one year.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07231471

• Comparing exercise programs for long head biceps tendinopathy

  We will try 12 weeks of eccentric or combined exercise programs versus a control exercise to see if they reduce shoulder pain and tendon thickness in people with long head biceps tendinopathy.

  Recruiting Hacettepe University · Ankara · NCT07025668

• Using OSTENIL® TENDON to treat pain and mobility issues in tendon disorders

  This study is testing if OSTENIL® TENDON can help people with tendon pain and mobility issues feel better in everyday life.

  Recruiting TRB Chemedica AG · Berlin, State of Berlin and 5 other locations · NCT06681051

• Using advanced ultrasound to track blood flow in healthy and injured tendons

  This study is testing a new ultrasound method to see if it can help spot differences in blood flow in healthy and injured tendons, specifically for people with overuse injuries like Achilles and patellar tendinopathy.

  Recruiting University Hospital Bispebjerg and Frederiksberg · Copenhagen · NCT06142747

• Embolization treatment for chronic shoulder pain

  This study is testing if adding a special procedure called embolization to physical therapy can help people with ongoing shoulder pain from rotator cuff issues feel better compared to just doing physical therapy alone.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06095050

• Endoscopic surgery for iliopsoas tendon pain relief

  This study is testing two different surgical methods to relieve hip pain caused by iliopsoas tendon issues in patients with hip replacements to see which one works better.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lyon · NCT05950022

• Treatment for Achilles Tendinopathy with Collagen and Physiotherapy

  This study tests if a new collagen treatment combined with physiotherapy can help people with Achilles tendinopathy feel less pain and move better compared to just physiotherapy alone.

  Recruiting Guna S.p.a · Roma, RO · NCT05464498

• Evaluating ketorolac for treating upper extremity joint and tendon pain

  This study is testing whether ketorolac or triamcinolone injections can help people with joint and tendon pain in their shoulders, elbows, wrists, and hands feel better and improve their function.

  Recruiting at 4 sites Phase 4 Emory University · Atlanta, Georgia and 3 other locations · NCT05292339

NIH-funded research (21)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Personalized Achilles tendon rehab: how loading in daily life affects healing

  A person with mid-substance Achilles tendinopathy could benefit from a personalized rehab plan based on how their daily activities load the tendon.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11581469

• Achilles Tendinopathy Center of Translation

  A center-led program aims to uncover basic science and translational tools to improve care for people with Achilles tendinopathy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11467321

• Understanding the muscle-subtendon units in Achilles tendinopathy

  This project explores why Achilles tendinopathy affects people differently by looking closely at the ankle’s tendon structure and how it responds to treatments.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11399785

• Exosome-based biologic treatment for tendinopathy

  A new exosome-based therapy called Altenex aims to treat tendinopathy safely and effectively in adults.

  NIH research New York/r&d/ctr/translational Med/ther · New Rochelle, UNITED STATES · NIH-11395416

• Quantifying Achilles Tendon Stress in Dancers to Prevent Tendinopathy

  Aimed at female ballet dancers, this project will measure Achilles tendon stress during dance and develop better tools to monitor pain and guide injury prevention and recovery.

  NIH research Brigham Young University · Provo, United States · NIH-11360319

• Role of CaV1.2 calcium channels in Achilles tendinopathy

  This grant explores how a calcium channel called CaV1.2 may drive tendinopathy in the Achilles tendon and what this could mean for new treatments.

  NIH research University of Rochester · Rochester, United States · NIH-11358381

• Patient-specific factors that influence recovery from rotator cuff tendinopathy

  Aims to understand why some people recover better from shoulder tendon problems than others and how to tailor resistance exercise to each person.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11357704

• Understanding and treating Achilles tendon injuries

  This study is looking into what causes Achilles tendinopathy to find better treatments, so if you’re dealing with this condition, the goal is to help you feel better and improve your quality of life.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11255211

• Center to Improve Treatments for Achilles Tendon Problems

  This program develops new lab models, tools, and treatment ideas to help people with Achilles tendon pain and disability.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11252803

• Finding the best tendon loading to help Achilles tendon heal

  This project looks at different ways people load their Achilles tendon during rehab and daily life to help those with Achilles tendon pain recover better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11251618

• How tendon loading affects healing in Achilles injuries

  This study is looking at how different ways of using your Achilles tendon can help it heal better if you have Achilles tendinopathy, and it aims to create personalized rehab plans to speed up recovery for people dealing with this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11238122

• How calf muscle mechanics affect Achilles tendon problems

  This project examines how calf muscle control and tendon loading relate to pain and healing in people with chronic mid-portion Achilles tendon problems.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11182492

• Understanding Recovery from Rotator Cuff Pain

  This work aims to understand why some people recover well from rotator cuff pain with exercise, while others continue to experience discomfort.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11128590

• Exosome injection to help damaged tendons

  A new injection made from stem-cell exosomes (called Altenex) aims to help people with tendinopathy — painful, worn-down tendons — heal better and reduce pain.

  NIH research New York/r&d/ctr/translational Med/ther · New Rochelle, UNITED STATES · NIH-11122314

• Understanding and treating Achilles tendon injuries

  This study is looking into what causes Achilles tendinopathy to help create better treatments, so if you’re dealing with this painful condition, you might benefit from new and improved ways to manage it.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11015873

• How tendon loading affects healing in Achilles injuries

  This study is looking at how different ways of using your Achilles tendon can help it heal better if you have Achilles tendinopathy, and it aims to create personalized rehab plans to improve your recovery based on how your tendon behaves during daily activities.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10986967

• Understanding recovery factors in shoulder pain from rotator cuff issues

  This study is looking at how different personal factors, like muscle strength and mindset, can help improve recovery from shoulder pain caused by rotator cuff tendinopathy, so we can create better exercise treatments that fit each person's needs.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10978161

• New treatment for tendon deterioration using exosomes

  This study is testing a new treatment called Altenex, which uses tiny particles from human stem cells to help heal painful tendon injuries and improve how they work, giving hope to people with tendinopathy.

  NIH research New York/r&d/ctr/translational Med/ther · New Rochelle, UNITED STATES · NIH-10921023

• Creating a new care model for chronic knee tendon pain

  This study is looking to help people with chronic knee pain from patellar tendinopathy by creating a new care plan that considers all aspects of their health, including their lifestyle and social factors, to make treatments more effective and improve their overall quality of life.

  NIH research Duke University · Durham, United States · NIH-10904918

• Understanding the mechanics behind Achilles tendon pain

  This study is looking at how different movements and muscle activities affect healing and pain in people with Achilles tendinopathy, so we can find better ways to help you recover and feel better.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10897990

• New treatment for tendon disorders using microRNA

  This study is testing a new treatment using a special molecule to help heal painful tendon issues, especially for older adults, and if it works well in animals, it could eventually be available for people like you who are dealing with tendinopathy.

  NIH research New York/r&d/ctr/translational Med/ther · New Rochelle, UNITED STATES · NIH-10884445

Related topics

Quick answers

How many Tendinopathy clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (4 trials), Germany (1 trial), France (1 trial), Spain (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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