Hyaluronic Acid vs Platelet-R-rich Plasma for Chronic Tendinopathy and Enthesopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two injectable approaches for chronic tendinopathy and enthesopathy. Participants have long-standing symptoms (over 3 months) with moderate to severe pain and are between 18 and 65 years old. The interventions are outpatient injections of hyaluronic acid or autologous PRP, aiming to support tendon and enthesis regeneration while minimizing safety risks. The study focuses on the elbow (medial epicondylopathy) and Achilles tendon region and excludes recent injections, prior surgery for the target tendon, infections, pregnancy, autoimmune conditions, and BMI 40 or higher. Outcomes likely center on pain and function, with safety monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic tendinopathy or enthesopathy of the Achilles tendon or tendon insertion in the elbow region (medial epicondylopathy, so-called golfer's elbow)
* Symptom duration exceeding 3 months
* Pain intensity of at least 40 millimeters (mm) on a 100-mm Visual Analog Scale (VAS)
* Age 18-65 years
* Signed written informed consent

Exclusion Criteria:

* Previous surgical treatment of the studied tendon or tendon insertion
* Prior injection of corticosteroids, platelet-rich plasma (PRP), or hyaluronic acid into the area being studied within 3 months before enrollment
* Active systemic or local infection at the planned injection site
* Systemic inflammatory or autoimmune disease involving the joints, including rheumatoid arthritis, spondyloarthritis, or systemic lupus erythematosus
* Pregnancy or breastfeeding
* Body mass index (BMI) of 40 kilograms per square meter (kg/m²) or greater

Where it's running

• Ortonika Orthopedic Medical Clinic in Lublin
  Lublin, Lublin Voivodeship, Poland Recruiting

Study contacts

• Principal investigator: Tomasz Wnuk, MD, PhD — Ortonika Orthopedic Medical Clinic
• Study coordinator: Tomasz Wnuk, MD, PhD
• Email: tomashorto@gmail.com
• Phone: +48 538 360 332

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.