Condition

Syphilis clinical trials and research

• 13Clinical trials
• 53NIH research projects
• 10Countries

Newest Syphilis clinical trials

All recruiting trials (13)

• Doxycycline to prevent bacterial STIs in sexual and gender minorities in Rio de Janeiro.

  This research will try taking doxycycline after sex to see if it lowers the chance of syphilis, gonorrhea, and chlamydia for men who have sex with men, transgender women, and travestis in Rio de Janeiro who are living with HIV or using PrEP.

  Recruiting Oswaldo Cruz Foundation · Rio de Janeiro, Rio de Janeiro · NCT07500415

• Rapid HIV, HCV, and syphilis screening at a rural street-medicine clinic

  A rapid fingerstick test is being tested in a mobile street-medicine clinic to see if it increases uptake and quick linkage to care for HIV, HCV, and syphilis among adults served by WVU Street Medicine.

  Recruiting West Virginia University · Harpers Ferry, West Virginia · NCT07317687

• Where syphilis bacteria live and whether they can spread from symptom-free sites in women and men who have sex with women

  This study will test whether syphilis bacteria found on symptom-free body sites are alive and how long they can be detected in women and men who have sex with women only.

  Recruiting at 3 sites Monash University · Melbourne, Victoria and 8 other locations · NCT07300254

• MagIA H3S multiplex rapid blood test for HIV, hepatitis B and C, and syphilis

  This project will test a single blood-based point-of-care test that checks for HIV, hepatitis B and C, and syphilis using serum or plasma samples from people at sites in Ivory Coast and Kenya.

  Recruiting at 2 sites MagIA Diagnostics · Abidjan and 1 other locations · NCT07170748

• Rapid finger‑prick syphilis and HIV testing at a low‑barrier prenatal clinic

  We will test if a five-minute finger‑prick syphilis/HIV test works for pregnant people who face barriers to prenatal care to speed diagnosis and treatment.

  Recruiting McMaster University · Hamilton, Ontario · NCT06829602

• Doxycycline Prophylaxis to Prevent STIs in Adolescent and Young Women

  This trial tests whether taking doxycycline after sex or every week can reduce gonorrhea, chlamydia, and early syphilis in girls and young women, compared with usual care.

  Recruiting at 12 sites Phase 4 Westat · Los Angeles, California and 12 other locations · NCT06738407

• Daily doxycycline treatment for early syphilis

  This study is testing if taking a daily pill of doxycycline for 14 days can effectively treat early syphilis in a small group of 15 people.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT06683638

• Routine and rapid point-of-care syphilis testing for pregnant people in the ER and OB triage

  This project will offer quick point-of-care and standard lab syphilis tests in the emergency department and obstetric triage to see if that helps pregnant people without prenatal care get diagnosed and start treatment sooner.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT06645106

• MedMira Multiplo rapid syphilis antibody test used at an Ottawa sexual health clinic

  This will test the MedMira Multiplo point-of-care syphilis antibody test on people aged 16 and older who are getting syphilis testing at an Ottawa sexual health clinic.

  Recruiting MedMira Laboratories Inc. · Ottawa, Ontario · NCT06586905

• Free testing and treatment program for chlamydia, gonorrhea, syphilis, and HIV

  This program offers free testing for four STIs and provides counseling and no-cost expedited treatment options for Black people aged 15–26 who live or spend most of their time in Orleans Parish.

  Recruiting Tulane University · New Orleans, Louisiana · NCT06428643

• Improving syphilis testing for pregnant women and newborns

  This study is testing two new ways to improve syphilis testing for pregnant women and their newborns to make sure they get the right care.

  Recruiting at 9 sites The University of Texas Health Science Center, Houston · Los Angeles, California and 8 other locations · NCT06082453

• Observing HIV infection risks among high-risk individuals in Vienna

  This study looks at the risk factors for new HIV infections among HIV-negative men who have sex with men and transgender individuals in Vienna to better understand how the virus spreads in these groups.

  Recruiting Medical University of Vienna · Vienna · NCT05326061

• Evaluating cefixime for treating syphilis

  This study is testing if cefixime can effectively treat early syphilis in patients, including those with HIV, as an alternative to the standard penicillin treatment.

  Recruiting Phase 3 University of Southern California · Los Angeles, California · NCT04958122

NIH-funded research (newest 40 of 53)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Syphilis in Pregnancy: Understanding Infection in Moms and Babies

  A study following pregnant women with syphilis and their babies to learn how the infection affects pregnancy and newborn health.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11565924

• Syphilis in Pregnancy: Molecular Tests and Immune Responses in Mom and Baby

  A study to understand how syphilis affects pregnancy and newborns by using molecular tests and tracking immune responses in 750 pregnant women with syphilis and their babies.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11565923

• Crowdsourced digital messaging to boost syphilis and HIV testing for women in NYC and rural Alabama

  A community-driven project tests whether crowdsourced digital messages can encourage women, especially women of color and Native American women, to get syphilis, HIV, and STI tests.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11470898

• Preventing syphilis in pregnant people in Rio de Janeiro

  A clinical trial in Brazil tests a pregnancy-safe antibiotic plan to stop syphilis from affecting babies.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11458760

• Cefixime vs Penicillin G for Early Syphilis in HIV and non-HIV patients

  This project compares a cefixime-based treatment to standard penicillin for early syphilis in people with and without HIV.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11401409

• Preventing congenital syphilis in pregnant people at risk in Rio de Janeiro

  A clinical trial will test a treatment approach during pregnancy to reduce syphilis transmission from mother to baby for pregnant people at risk in Rio de Janeiro.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11399881

• Ending the syphilis epidemic in the US with smarter models

  A Johns Hopkins team will use advanced computer models to find the most cost-effective ways to reduce syphilis infections in US communities.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11397529

• Syphilis in Pregnancy: Molecular Tests and Immune Responses in Moms and Babies

  This study follows pregnant women with syphilis and their babies to understand how the infection affects both, using advanced tests to learn more about the immune response and how the infection passes to the baby.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11392402

• Helping women in South Africa self-test for HIV and syphilis and connect to PrEP or treatment

  This project will design ways to help women in South Africa use combined HIV and syphilis self-tests and get linked to treatment or PrEP.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11388812

• Understanding syphilis immunity to improve care and vaccine development

  Researchers will follow people with new and repeat syphilis infections in Lima, Peru to learn how their immune systems respond.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11386345

• Improving testing and immune care for syphilis in pregnancy

  Researchers will use advanced lab tests and follow pregnant women with syphilis and their babies to learn how the infection and immune responses affect birth outcomes.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11378629

• Syphilis in pregnancy: improved tests and mother–baby immune responses

  This project looks at better laboratory tests and how mothers' and newborns' immune systems respond to syphilis in pregnant people in Cameroon and Zambia.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11376430

• Local and systemic immune responses during syphilis infection

  This project aims to understand how the immune system responds to syphilis in order to help design a better vaccine for people affected by the infection.

  NIH research University of Washington · Seattle, United States · NIH-11369837

• Chimeric vaccine to prevent syphilis and congenital transmission

  This project is creating a combined vaccine designed to stop syphilis infection, its spread through the body, and transmission to unborn babies.

  NIH research University of Victoria · Victoria, Canada · NIH-11325887

• Support for South African women to self-test for HIV and syphilis and connect to treatment or PrEP

  This project will create ways to help women in South Africa use combined HIV and syphilis self-tests and get linked to HIV treatment, syphilis care, or PrEP.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11322510

• A vaccine to prevent syphilis by targeting the bacterium's outer membrane proteins

  This project is developing a vaccine to help protect people worldwide—especially those at higher risk—from syphilis by teaching the immune system to recognize the bacterium's surface proteins.

  NIH research Duke University · Durham, United States · NIH-11322149

• Creating a new treatment for syphilis

  This study is looking for a new way to treat syphilis for people who might not get better with the usual medicines, aiming to help them feel better and improve their health.

  NIH research Nanohmics, INC. · Austin, United States · NIH-11307371

• Developing a new treatment for syphilis

  This study is looking for a new way to treat syphilis, a sexually transmitted infection, and it invites patients to help find a better treatment that could work well for everyone.

  NIH research Fox Chase Chemical Diversity Center, INC · Doylestown, United States · NIH-11306916

• Rapid combined antibody test to detect active syphilis

  A point-of-care test that looks for both treponemal and non-treponemal antibodies to help tell if someone has active syphilis or a past infection.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11291884

• Congenital Syphilis: Amoxicillin vs Penicillin for Newborns

  A new trial will compare an oral antibiotic (amoxicillin) with the standard shot (benzathine penicillin) for babies with possible congenital syphilis to see which works better.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11258325

• Improving newborn syphilis testing

  This project will use newer lab tests on mothers and newborns to find syphilis earlier so babies can get treatment sooner.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11241983

• Finding new treatments for syphilis.

  This study is looking for new and better ways to treat syphilis, so patients can have more effective options with fewer side effects than the usual treatment.

  NIH research Chromologic, LLC · Monrovia, United States · NIH-11203271

• Detecting early syphilis using unique bacterial fragments

  This study is looking at a new way to quickly and accurately detect syphilis by using tiny pieces of the bacteria that cause it, which could help people get treated faster than with current tests.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11196339

• Rapid point-of-care test for syphilis and other genital ulcer infections

  A small, portable molecular test to quickly detect syphilis (and other causes of genital ulcers) for adults in clinic settings.

  NIH research Magic Lifescience, INC. · Mountain View, United States · NIH-11174434

• Improving molecular tests for congenital syphilis

  Checking how the way samples are collected and handled affects a new molecular test that aims to directly detect syphilis in pregnant people and newborns.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11173804

• Better tests to find syphilis in pregnant people and newborns

  This project is testing new, faster molecular and microbiome-based tests to detect syphilis in pregnant people and newborns.

  NIH research University of Texas at Austin · Austin, United States · NIH-11167820

• A direct, point-of-care test to detect infectious and congenital syphilis

  A new diagnostic test is being developed to directly detect active syphilis infections, including congenital cases, and to work at the point of care.

  NIH research University of Victoria · Victoria, Canada · NIH-11166664

• New molecular tests to diagnose syphilis in pregnancy and track treatment

  Researchers are looking for blood-based molecular signals that could help diagnose syphilis during pregnancy and show whether treatment worked.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11159726

• Comparing an oral antibiotic (cefixime) to penicillin shots for early syphilis

  This trial compares taking cefixime pills versus receiving penicillin injections to treat early syphilis in people with and without HIV.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11159118

• Early syphilis detection by finding bacterial cell-wall fragments

  A lab test that looks for pieces of the syphilis bacterium to find infections much sooner in people who may have been exposed.

  NIH research Northwestern University · Chicago, United States · NIH-11145848

• Investigating the long-term risks of neurosyphilis in HIV-positive individuals with unusual syphilis test results

  This study is looking at people with HIV who have unusual results on their syphilis tests to see if they might be at risk for neurosyphilis, helping doctors figure out if more tests are needed and how to better care for these patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11142631

• Improving syphilis screening using a new testing method

  This study is testing a new way to quickly detect syphilis in men who have sex with men and transgender individuals, using different types of samples like blood and rectal swabs, to help find infections earlier than current tests do.

  NIH research University of Washington · Seattle, United States · NIH-11142569

• Understanding how infants' immune systems respond to congenital syphilis infection

  This study is looking at how the immune systems of babies who might have been exposed to syphilis at birth respond, especially in those who don’t show any signs of infection, to help create better tests that can tell which babies are actually infected so they can get the right care without unnecessary treatments.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11138753

• A new test to quickly diagnose syphilis infections

  This study is working on a quick and easy test for syphilis that can tell if you have an active infection or if you've been treated before, helping doctors make better treatment choices for you.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11133184

• Understanding how syphilis bacteria cause disease

  This study is looking at how the bacteria that cause syphilis manage to infect and stay in the body, with the hope of finding new ways to help control this important health issue, especially for those at higher risk.

  NIH research University of Washington · Seattle, United States · NIH-11131626

• Emergency Department Screening for Syphilis

  This project is developing a new way to check for syphilis in emergency rooms to help people who might not get tested otherwise.

  NIH research University of Chicago · Chicago, United States · NIH-11126671

• Syphilis during pregnancy: improving tests and tracking mother and baby immune responses

  This project will use molecular tests and close follow-up of pregnant women and their newborns to learn how syphilis affects mothers and babies.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11105870

• Developing a vaccine to prevent syphilis using outer membrane proteins.

  This study is working on a new vaccine to help prevent syphilis by focusing on certain proteins from the bacteria that cause it, and if successful, it could offer protection for people at risk of this infection.

  NIH research Duke University · Durham, United States · NIH-11077819

• Creating a new vaccine to prevent syphilis infections

  This study is working on a new vaccine to help protect against syphilis, a sexually transmitted infection that's becoming more common, by testing important proteins from the bacteria that cause it in animals to see if they can help the body fight off the infection.

  NIH research University of Victoria · Victoria, Canada · NIH-11075298

• Improving tests for congenital syphilis in newborns

  This study is looking at new ways to quickly and accurately test newborns for congenital syphilis, so that mothers and their babies can get the right care sooner and avoid serious health problems.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10983764

Related topics

Quick answers

How many Syphilis clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (7 trials), Canada (2 trials), Australia (1 trial), China (1 trial), South Africa (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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