Creating a new treatment for syphilis
Official title: Development of a Treatment for Syphilis
Funded at Nanohmics, INC. · NIH-11307371 · Data updated 2026-11-12
This study is looking for a new way to treat syphilis for people who might not get better with the usual medicines, aiming to help them feel better and improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nanohmics, INC. NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | November 15, 2024 |
| Project end | November 14, 2025 |
| Funding year | 2025 |
| Award (this year) | $299,868 |
| NIH project number | 75N93025C00010-0-9999-1 |
| Project ID | NIH-11307371 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with syphilis who may benefit from alternative treatment options.
✕Less likely to help
Patients who have already been effectively treated for syphilis with existing therapies may not receive additional benefits from this research.
What this research studies
This research focuses on developing an alternative treatment for syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. The approach aims to create a therapeutic agent that could provide effective treatment options for patients who may not respond to existing therapies. By exploring innovative methods in therapeutic development, the research seeks to improve patient outcomes and address the challenges associated with current treatment options.
Why it matters
Potential benefit: If successful, this research could provide a new and effective treatment option for patients with syphilis.
How similar studies have gone: While there have been various approaches to treating syphilis, the development of alternative treatments is an area that continues to seek innovative solutions, indicating a mix of both novel and tested methodologies.
Where this research is happening
-
Nanohmics, INC.
Austin, United States Active
Researchers
- Principal investigator: Savoy, Steve Michael — Nanohmics, INC.
- Study coordinator: Savoy, Steve Michael
Related research
Other NIH-funded projects on the same topics.
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Syphilis in Pregnancy: Understanding Infection in Moms and Babies
A study following pregnant women with syphilis and their babies to learn how the infection affects pregnancy and newborn health.
-
Syphilis in Pregnancy: Molecular Tests and Immune Responses in Mom and Baby
A study to understand how syphilis affects pregnancy and newborns by using molecular tests and tracking immune responses in 750 pregnant women with syphilis and their babies.
-
Crowdsourced digital messaging to boost syphilis and HIV testing for women in NYC and rural Alabama
A community-driven project tests whether crowdsourced digital messages can encourage women, especially women of color and Native American women, to get syphilis, HIV, and STI tests.
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Preventing syphilis in pregnant people in Rio de Janeiro
A clinical trial in Brazil tests a pregnancy-safe antibiotic plan to stop syphilis from affecting babies.
-
Cefixime vs Penicillin G for Early Syphilis in HIV and non-HIV patients
This project compares a cefixime-based treatment to standard penicillin for early syphilis in people with and without HIV.
-
Preventing congenital syphilis in pregnant people at risk in Rio de Janeiro
A clinical trial will test a treatment approach during pregnancy to reduce syphilis transmission from mother to baby for pregnant people at risk in Rio de Janeiro.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.