Finding new treatments for syphilis.
Official title: SBIR Topic 134: Alternatives to Benzathine Penicillin for Treatment of Syphilis
Funded at Chromologic, LLC · NIH-11203271 · Data updated 2026-11-12
This study is looking for new and better ways to treat syphilis, so patients can have more effective options with fewer side effects than the usual treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chromologic, LLC NIH-funded |
| Lab location | 1 site (Monrovia, United States) |
| Project start | September 25, 2024 |
| Project end | September 24, 2025 |
| Funding year | 2024 |
| Award (this year) | $299,914 |
| NIH project number | 75N93024C00032-0-9999-1 |
| Project ID | NIH-11203271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with syphilis who may benefit from alternative treatment options.
✕Less likely to help
Patients who have already been effectively treated with Benzathine Penicillin may not receive additional benefits from this research.
What this research studies
This research focuses on developing alternative therapeutics for the treatment of syphilis, a sexually transmitted infection. The project aims to identify and create new treatment options that could be more effective or have fewer side effects than the current standard, Benzathine Penicillin. By exploring innovative therapeutic agents, the research seeks to improve patient outcomes and address the growing need for effective syphilis treatments. Patients may be involved in trials or benefit from new therapies developed through this initiative.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective and safer treatment options for syphilis.
How similar studies have gone: While there have been various approaches to treating syphilis, this research aims to explore novel alternatives, making it a potentially innovative endeavor.
Where this research is happening
-
Chromologic, LLC
Monrovia, United States Active
Researchers
- Principal investigator: Jimenz, Jorge — Chromologic, LLC
- Study coordinator: Jimenz, Jorge
Related research
Other NIH-funded projects on the same topics.
-
Syphilis in Pregnancy: Understanding Infection in Moms and Babies
A study following pregnant women with syphilis and their babies to learn how the infection affects pregnancy and newborn health.
-
Syphilis in Pregnancy: Molecular Tests and Immune Responses in Mom and Baby
A study to understand how syphilis affects pregnancy and newborns by using molecular tests and tracking immune responses in 750 pregnant women with syphilis and their babies.
-
Crowdsourced digital messaging to boost syphilis and HIV testing for women in NYC and rural Alabama
A community-driven project tests whether crowdsourced digital messages can encourage women, especially women of color and Native American women, to get syphilis, HIV, and STI tests.
-
Preventing syphilis in pregnant people in Rio de Janeiro
A clinical trial in Brazil tests a pregnancy-safe antibiotic plan to stop syphilis from affecting babies.
-
Cefixime vs Penicillin G for Early Syphilis in HIV and non-HIV patients
This project compares a cefixime-based treatment to standard penicillin for early syphilis in people with and without HIV.
-
Preventing congenital syphilis in pregnant people at risk in Rio de Janeiro
A clinical trial will test a treatment approach during pregnancy to reduce syphilis transmission from mother to baby for pregnant people at risk in Rio de Janeiro.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.