Condition

Human Immunodeficiency Virus clinical trials and research

• 19Clinical trials
• 3NIH research projects
• 9Countries

Newest Human Immunodeficiency Virus clinical trials

All recruiting trials (19)

• ICVAX therapeutic DNA vaccine for people living with HIV in Hong Kong

  This trial tests whether the ICVAX DNA vaccine, given with three different delivery devices, is safe and boosts HIV-specific T-cell responses in adults on stable antiretroviral therapy.

  Recruiting Phase 1 Yicura Holding (HK) Limited · Shatin, New Territories · NCT07530198

• Adding lenacapavir to ART to try to shrink hidden HIV reservoirs

  This study will test whether giving lenacapavir in addition to a stable ART regimen can reduce hidden HIV reservoirs in adults who have had undetectable viral loads for at least three years.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06819176

• SUSTAIN 2: Sustained HIV treatment support after interruptions in care

  This trial will test whether a six-month adherence club model with multi-month ART dispensing and peer support helps adults with HIV who missed care or have a raised viral load stay on treatment and reach viral suppression over 24 months.

  Recruiting Brigham and Women's Hospital · Cape Town · NCT06554223

• Long-acting injectable treatment for HIV in Belgium

  This study is looking to see how well people with HIV feel about and respond to a long-acting injectable treatment they’ve received.

  Recruiting Belgian Research on AIDS and HIV Consortium · Brussels · NCT06424964

• Universal Test and Connect for HIV services in Cape Town emergency departments

  This project tests whether offering universal HIV testing and connection-to-care in two Cape Town emergency departments can find people with HIV or at high risk and link them to treatment or PrEP.

  Recruiting Johns Hopkins University · Cape Town, Western Cape · NCT06408142

• Evaluating a new HIV vaccine combination in healthy adults

  This study is testing a new combination of HIV vaccines in healthy adults to see if they are safe and can help the body build protection against the virus.

  Recruiting Phase 1 U.S. Army Medical Research and Development Command · Kampala · NCT06205056

• Exploring the effects of gut microbiota on inflammation in people with HIV and alcohol use disorder

  This study tests whether taking prebiotics can help reduce inflammation and improve gut health in people with HIV who also struggle with alcohol use disorder.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT06139224

• Improving mental health care for pregnant women with HIV in Kenya

  This study is testing a new way to combine mental health support with regular care for pregnant women living with HIV in Kenya to see if it helps them feel better and manage their health.

  Recruiting University of Colorado, Denver · Nairobi · NCT06117163

• Helping people with HIV quit smoking in India

  This study is testing if a combination of a smoking cessation medication and a mobile support program can help people with HIV in India quit smoking more effectively than standard care.

  Recruiting at 2 sites Phase 3 University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05786547

• Educational text messages to improve heart health in people with HIV

  This study tests if sending educational text messages can help people over 40 with HIV make better choices for their heart health.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT05642858

• Using low dose naltrexone to treat pain in HIV patients

  This study is testing whether low dose naltrexone can help relieve chronic pain in people living with HIV.

  Recruiting at 3 sites Phase 4 Emory University · Atlanta, Georgia and 2 other locations · NCT05537935

• Reduced dosing of the HPV vaccine for women living with HIV

  This study is testing if a lower dose of the HPV vaccine can effectively protect women living with HIV from HPV and cervical cancer.

  Recruiting at 5 sites Phase 4 University of British Columbia · Surrey, British Columbia and 9 other locations · NCT05495906

• Using Baricitinib to Target HIV in the Central Nervous System

  This study is testing if the medication baricitinib can help reduce HIV in the brain for people living with HIV who are already on stable treatment.

  Recruiting at 2 sites Phase 2 Emory University · Atlanta, Georgia and 1 other locations · NCT05452564

• Evaluating the Gardasil-9 HPV vaccine in adults with HIV

  This study is testing how well the Gardasil-9 HPV vaccine works for adults with well-controlled HIV to see if their immune response is similar to those without HIV.

  Recruiting Phase 4 Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT05266898

• Transplanting organs from HIV-positive donors to HIV-positive recipients

  This study is testing whether kidney transplants from HIV-positive donors to HIV-positive recipients are safe and effective for people living with HIV.

  Recruiting Tulane University · Metairie, Louisiana · NCT05159466

• Evaluating cefixime for treating syphilis

  This study is testing if cefixime can effectively treat early syphilis in patients, including those with HIV, as an alternative to the standard penicillin treatment.

  Recruiting Phase 3 University of Southern California · Los Angeles, California · NCT04958122

• Nice HIV Cohort Follow-Up

  This project follows people with HIV who have scheduled outpatient visits to see how their health changes over time using routine medical records.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT03690063

• Exploring genetic factors in viral-associated tumors and immune disorders

  This study is trying to find out how genetic factors in tumors linked to viral infections affect people with HIV, immune disorders, or Castleman disease, to help improve diagnosis and treatment.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03300830

• Using donor T cells to treat cancer patients with BK and JC viruses

  This study is testing if infusions of special immune cells from donors can help cancer patients with BK or JC virus infections feel better and fight their illness.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT02479698

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Evaluating cervical cancer screening methods for women with HIV in Botswana

  This study is looking at the best ways to screen for cervical cancer in women living with HIV in Botswana, and it invites 3,000 women to help find out which testing methods work best for keeping them healthy.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11093576

• How stigma and social support affect cognitive function in older women with HIV

  This study is looking at how stigma related to HIV and gender affects the thinking skills of older women living with HIV/AIDS, and it also wants to see if having good social support can help protect their mental health.

  NIH research Yale University · New Haven, United States · NIH-11009236

• The relationship between oral bacteria and tooth decay in children with HIV

  This study looks at how the germs in the mouths of children with HIV might affect their risk of getting cavities, and it aims to find ways to help keep their teeth healthy.

  NIH research Clemson University · Clemson, United States · NIH-10424444

Related topics

Quick answers

How many Human Immunodeficiency Virus clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (11 trials), South Africa (2 trials), Canada (1 trial), Uganda (1 trial), Kenya (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 4: 3, Phase 3: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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