Condition

Spasticity clinical trials and research

• 15Clinical trials
• 13NIH research projects
• 2New in 30 days
• 18Countries

Newest Spasticity clinical trials

All recruiting trials (15)

• Shockwave therapy added to toxin injections to help spasticity after spinal cord injury

  Aims to see if focused shockwave therapy plus Botox injections reduce spasticity better than Botox alone in adults with spinal cord injury.

  Recruiting Phase 2 Kessler Foundation · West Orange, New Jersey · NCT07894991

• Targeted spinal cord stimulation to reduce spasticity in spinal cord injury

  This study tests whether an implanted epidural stimulator can help reduce severe spasticity and improve voluntary movement in adults with spinal cord injury.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT07890558

• Photobiomodulation to Help Spasticity After Stroke

  This trial tests whether matching low-level light therapy can reduce leg muscle tightness in adults who have had a stroke and developed spasticity.

  Recruiting Phase 1/2 University of Nove de Julho · São Paulo, São Paulo · NCT07784231

• Dorsal Root Electrical Stimulation to Help Spasticity in Children with Cerebral Palsy

  This study tests whether adding dorsal root electrical stimulation during SDR surgery can lessen spasticity in children with cerebral palsy.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07715006

• Cryoneurolysis for Chronic Pain: 6- and 12-Month Outcomes in Routine Care

  This study tests whether cryoneurolysis, done as part of standard care for people with chronic pain, leads to meaningful improvements over 6 to 12 months.

  Recruiting Yale University · Old Saybrook, Connecticut · NCT07639060

• Gentle spinal stimulation to reduce muscle tightness in children with cerebral palsy

  This will try non-invasive, light spinal cord stimulation with movement tests to see if it reduces spasticity in children ages 5–17 with cerebral palsy.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07516067

• Focused shockwave treatment for elbow and wrist spasticity after spinal cord injury

  This project will try focused extracorporeal shockwave therapy on the elbow and wrist to reduce spasticity in adults with chronic spinal cord injury.

  Recruiting Phase 1 Kessler Foundation · West Orange, New Jersey · NCT07501429

• At-home full-body stimulation suit to manage spasticity and ataxia in MS

  This project will try whether wearing a full-body electrical stimulation suit for six weeks helps people with MS who have spasticity or ataxia reduce symptoms and improve daily functioning.

  Recruiting at 2 sites Universitair Ziekenhuis Brussel · Steenokkerzeel and 1 other locations · NCT07202195

• Registry and biobank for neuroimmunological diseases

  This study is trying to see if certain antibodies in the brain are linked to neurological disorders like encephalopathy and psychosis, and how they might affect patients' health.

  Recruiting at 2 sites Charite University, Berlin, Germany · Berlin, State of Berlin and 1 other locations · NCT06958341

• Cryoneurolysis for shoulder pain and spasticity management

  This study tests if a new cold treatment for shoulder pain can help people with hemiplegia feel better and move better compared to the usual botulinum injections.

  Recruiting Centre National de Rééducation Fonctionnelle et de Réadaptation · Luxembourg · NCT06782464

• Muscle, tendon, and nerve changes after botulinum toxin injections for post-stroke spastic equinovarus

  This pilot will use 3D ultrasound and instrumented spasticity tests to see how botulinum toxin injections change muscle, tendon, and nerve properties in adults with post-stroke spastic equinovarus.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06767631

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Using dry needling to treat muscle tightness in people with Multiple Sclerosis

  This study is testing if dry needling can help people with Multiple Sclerosis reduce muscle tightness and improve their balance and walking.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06394310

• Wearable lower-limb exoskeleton to stretch legs and improve walking

  This research will test a portable wearable exoskeleton to help people with spasticity from spinal cord injury increase leg range of motion and improve walking.

  Recruiting VA Office of Research and Development · Syracuse, New York · NCT05926596

• IPN10200 treatment for adult upper limb spasticity after stroke or TBI

  This trial will test whether different doses of IPN10200 can reduce upper limb spasticity in adults after stroke or traumatic brain injury while monitoring safety.

  Recruiting at 54 sites Phase 1/2 Ipsen · Downey, California and 80 other locations · NCT04752774

NIH-funded research (13)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Wearable exoskeleton that provides on-demand leg stretching for people with spasticity

  This project offers a wearable robotic device that provides on-demand leg stretching to help people with spasticity from spinal cord injury or brain injury reduce spasms and improve movement.

  NIH research Syracuse VA Medical Center · Syracuse, United States · NIH-11472332

• Non-invasive spinal stimulation to help kids with cerebral palsy move and reduce stiffness

  This study tests a non-invasive spinal stimulation plus treadmill training to reduce spasticity and improve walking in children with cerebral palsy.

  NIH research University of Washington · Seattle, United States · NIH-11465091

• Shockwave therapy to help reduce spasticity after spinal cord injury

  A randomized, sham-controlled trial will test whether extracorporeal shockwave therapy can lessen muscle tightness in people with spinal cord injuries.

  NIH research Kessler Foundation, INC. · East Hanover, UNITED STATES · NIH-11438642

• Cerebellum-targeted deep brain stimulation for severe movement problems and spasticity in cerebral palsy

  This project tests whether implanted electrodes that stimulate a cerebellar motor area can reduce severe involuntary movements and muscle tightness in children and young adults with cerebral palsy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11322723

• Non‑invasive spinal stimulation to reduce spasms, pain, and improve movement after spinal cord injury

  This project uses gentle electrical pulses over the skin of the spine to reduce muscle spasms, ease neuropathic pain, and help movement for people with spinal cord injury.

  NIH research Shepherd Center · Atlanta, United States · NIH-11322017

• Using non-invasive stimulation to reduce spasticity and improve movement after spinal cord injury

  This study is looking at how gentle spinal cord stimulation can help people with spinal cord injuries feel less stiffness and regain better movement, making it a friendly option for improving recovery.

  NIH research Drexel University · Philadelphia, United States · NIH-11082205

• Using brain stimulation to improve movement in children with cerebral palsy

  This study is looking at how a special treatment called deep brain stimulation can help kids and young adults with cerebral palsy by improving their movement and reducing stiffness, and we're inviting ten participants to see if this approach makes a difference for them.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11055281

• Using Romidepsin to treat spasticity after spinal cord injury

  This study is testing a new way to deliver a medication called Romidepsin directly into the spinal canal to help people with muscle stiffness from spinal cord injuries feel more comfortable and improve their movement.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11014978

• Using a wearable exoskeleton to stretch legs for people with spasticity

  This study is testing a special wearable device that helps people with muscle tightness stretch their legs when they need it, making daily activities easier and improving their comfort and movement.

  NIH research Syracuse VA Medical Center · Syracuse, United States · NIH-11014368

• Understanding access to healthcare and telehealth for individuals with hand spasticity

  This study is looking at how people with hand spasticity can get the healthcare and support they need, especially with the rise of telehealth during the COVID-19 pandemic, and it aims to understand their challenges with technology so we can find better ways to help them live more independently and improve their quality

  NIH research University of Minnesota · Minneapolis, United States · NIH-10930867

• Improving muscle control and reducing pain in spinal cord injury patients using electrical stimulation

  This study is looking at how a special electrical treatment on the spinal cord can help people with spinal cord injuries feel less muscle tightness and pain, and possibly move better, so they can enjoy life more fully.

  NIH research Shepherd Center · Atlanta, United States · NIH-10847343

• Non-invasive electrical nerve block to reduce muscle spasticity

  This study is exploring a new way to help people with muscle tightness, like those with cerebral palsy, stroke, or spinal cord injuries, by using a gentle electrical technique that can reduce unwanted nerve signals and improve movement.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10814406

• Long-lasting delivery of Tizanidine to treat severe muscle stiffness

  This study is working on a new way to deliver Tizanidine, a medicine that helps with muscle tightness and spasms, to make it easier for people with conditions like cerebral palsy, multiple sclerosis, and spinal cord injuries to manage their symptoms and feel better.

  NIH research Delpor, INC. · South San Francisco, United States · NIH-10490906

Related topics

Quick answers

How many Spasticity clinical trials are recruiting right now?

15, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (9 trials), Germany (2 trials), Belgium (2 trials), Italy (2 trials), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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