Using Romidepsin to treat spasticity after spinal cord injury
Development of Long-term Intrathecal Romidepsin: A New Drug Candidate for SCI-Induced Spasticity
This study is testing a new way to deliver a medication called Romidepsin directly into the spinal canal to help people with muscle stiffness from spinal cord injuries feel more comfortable and improve their movement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Connecticut Healthcare System NIH-funded |
| Lab location | 1 site (West Haven, United States) |
| Project ID | NIH-11014978 on NIH RePORTER |
What this research studies
This research aims to develop a method for delivering Romidepsin directly into the spinal canal to treat spasticity caused by spinal cord injuries. The study will evaluate both the effectiveness and safety of this long-term treatment approach, focusing on how well it reduces muscle stiffness and improves patient comfort. By using an established catheter infusion method, researchers hope to provide a more effective solution for patients who suffer from chronic spasticity. The project will also explore the underlying mechanisms of how Romidepsin works in the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with spasticity resulting from spinal cord injuries who have not found relief from traditional treatments.
Not a fit: Patients with spasticity not related to spinal cord injuries or those who have contraindications to Romidepsin may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new long-term treatment option for patients suffering from spasticity due to spinal cord injuries.
How similar studies have performed: While the use of Romidepsin has shown promise in acute settings, this long-term intrathecal delivery method is relatively novel and has not been extensively tested in similar contexts.
Where this research is happening
West Haven, United States
- VA Connecticut Healthcare System — West Haven, United States (Active)
Researchers
- Principal investigator: Kauer, Sierra Dawn — VA Connecticut Healthcare System
- Study coordinator: Kauer, Sierra Dawn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.