Long-lasting delivery of Tizanidine to treat severe muscle stiffness
Official title: Sustained Delivery of Tizanidine for Maintenance Treatment of Moderate to Severe Spasticity
Funded at Delpor, INC. · NIH-10490906 · Data updated 2026-11-12
This study is working on a new way to deliver Tizanidine, a medicine that helps with muscle tightness and spasms, to make it easier for people with conditions like cerebral palsy, multiple sclerosis, and spinal cord injuries to manage their symptoms and feel better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Delpor, INC. NIH-funded |
| Lab location | 1 site (South San Francisco, United States) |
| Project start | April 15, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $1,246,488 |
| NIH project number | 5R44NS110135-03 |
| Project ID | NIH-10490906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults and children with moderate to severe spasticity due to conditions such as cerebral palsy, multiple sclerosis, or spinal cord injuries.
✕Less likely to help
Patients who do not experience spasticity or have mild forms of muscle stiffness may not benefit from this research.
What this research studies
This research focuses on developing a method for sustained delivery of Tizanidine, a medication used to treat spasticity, which is characterized by increased muscle tone and involuntary muscle contractions. The approach aims to provide a more consistent and effective treatment for patients suffering from conditions like cerebral palsy, multiple sclerosis, and spinal cord injuries, who often experience inadequate symptom relief with current treatment methods. By reducing the frequency of medication administration and minimizing side effects, this research seeks to improve the quality of life for patients with severe spasticity.
Why it matters
Potential benefit: If successful, this research could significantly enhance the management of spasticity, leading to improved daily functioning and quality of life for affected patients.
How similar studies have gone: Previous research has shown that sustained delivery systems for medications can improve treatment outcomes, indicating potential success for this novel approach.
Where this research is happening
-
Delpor, INC.
South San Francisco, United States Active
Researchers
- Principal investigator: Watkins, Gregory — Delpor, INC.
- Study coordinator: Watkins, Gregory
Related research
Other NIH-funded projects on the same topics.
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Wearable exoskeleton that provides on-demand leg stretching for people with spasticity
This project offers a wearable robotic device that provides on-demand leg stretching to help people with spasticity from spinal cord injury or brain injury reduce spasms and improve movement.
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Non-invasive spinal stimulation to help kids with cerebral palsy move and reduce stiffness
This study tests a non-invasive spinal stimulation plus treadmill training to reduce spasticity and improve walking in children with cerebral palsy.
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Shockwave therapy to help reduce spasticity after spinal cord injury
A randomized, sham-controlled trial will test whether extracorporeal shockwave therapy can lessen muscle tightness in people with spinal cord injuries.
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Cerebellum-targeted deep brain stimulation for severe movement problems and spasticity in cerebral palsy
This project tests whether implanted electrodes that stimulate a cerebellar motor area can reduce severe involuntary movements and muscle tightness in children and young adults with cerebral palsy.
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Non‑invasive spinal stimulation to reduce spasms, pain, and improve movement after spinal cord injury
This project uses gentle electrical pulses over the skin of the spine to reduce muscle spasms, ease neuropathic pain, and help movement for people with spinal cord injury.
-
Using non-invasive stimulation to reduce spasticity and improve movement after spinal cord injury
This study is looking at how gentle spinal cord stimulation can help people with spinal cord injuries feel less stiffness and regain better movement, making it a friendly option for improving recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.