Network for early diagnosis and management of AL amyloidosis in Italy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This initiative aims to create a network of Italian Hematologic Departments linked to the Amyloidosis Research and Treatment Center in Pavia. It focuses on implementing a biomarker-based screening strategy to promote early diagnosis of AL amyloidosis in at-risk patients, including those with monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. The project also seeks to facilitate patient referrals for ongoing clinical studies and to explore novel diagnostic technologies. By addressing the late diagnosis of AL amyloidosis, the study aims to improve patient outcomes through timely intervention.

Why it matters

Who can join: the full rules

PART A

Inclusion Criteria:

* diagnosis of MGUS with altered FLCR or SMM;
* treatment-naïve;
* age ≥18 years;
* ability to understand and willingness to sign an informed consent;
* planned follow-up at participating center.

Exclusion Criteria:

* Diagnosis of symptomatic monoclonal gammopathies;
* Previous treatment for monoclonal gammopathies.

PART B

Inclusion criteria:

* diagnosis of systemic AL amyloidosis;
* treatment-naïve;
* age ≥18 years;
* ability to understand and willingness to sign an informed consent;
* planned follow-up at participating center.

Exclusion criteria:

* non-AL amyloidosis;
* previous treatment for AL amyloidosis.

Where it's running

• Azienda Ospedaliera Policlinico Consorziale
  Bari, Italy Recruiting
• Azienda Ospedaliero Universitaria Policlinico G.Rodolico - San Marco
  Catania, Italy Recruiting
• Fondazione Irccs Policlinico San Matteo
  Pavia, Italy Recruiting
• EMATOLOGIA - Città della Scienza e Salute - Torino
  Torino, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.