Investigating the link between insulin resistance and Alzheimer's disease
Official title: Targeting Type 3 Diabetes (T3D) Mechanism of Alzheimer's Disease (AD) and AD-Related Dementias
Funded at Regene LLC · NIH-11014382 · Data updated 2026-11-12
This study is looking at how problems with insulin in the brain might be linked to Alzheimer's disease and aims to find new ways to help improve thinking and memory for people dealing with this condition.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regene LLC NIH-funded |
| Lab location | 1 site (Belchertown, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $249,995 |
| NIH project number | 5R43AG085738-02 |
| Project ID | NIH-11014382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive decline or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia unrelated to insulin resistance may not benefit from this research.
What this research studies
This research explores the connection between insulin resistance in the brain and the development of Alzheimer's disease (AD) and related dementias. It focuses on a hypothesis known as Type 3 Diabetes (T3D), which suggests that disruptions in insulin signaling may contribute to cognitive decline in aging individuals. The study will utilize various models to investigate the underlying mechanisms of T3D and how they relate to AD pathology. By understanding these processes, the research aims to identify potential therapeutic targets for improving cognitive function in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in exploring the role of insulin signaling in cognitive decline, suggesting that this approach could yield significant insights.
Where this research is happening
-
Regene LLC
Belchertown, United States Active
Researchers
- Principal investigator: Suvorov, Alexander — Regene LLC
- Study coordinator: Suvorov, Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.