Investigating how a high fat diet affects Alzheimer's disease differently in men and women and if nilotinib can help.
Sex-based differences of a high fat diet in Alzheimer's disease (AD): Can nilotinib reverse bioenergetic and neuropathological deficits?
This study is looking at how a high-fat diet affects Alzheimer's disease differently in men and women, and it will test if a leukemia drug called nilotinib can help improve brain health and memory in mice that are on this diet.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project ID | NIH-11061864 on NIH RePORTER |
What this research studies
This research explores the impact of a high fat diet on Alzheimer's disease, focusing on how metabolic disorders like obesity and diabetes may influence the disease differently in men and women. The study uses a mouse model to assess bioenergetic, cognitive, and neuropathological outcomes associated with Alzheimer's. Researchers will evaluate whether nilotinib, a drug originally developed for leukemia, can reverse the negative effects of a high fat diet on these outcomes. By understanding these differences, the research aims to identify more effective treatments for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with metabolic disorders such as obesity or diabetes.
Not a fit: Patients who do not have metabolic disorders or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for Alzheimer's disease that take into account sex-based differences.
How similar studies have performed: Previous studies have shown promise in using nilotinib for treating neurodegenerative diseases, indicating potential for success in this novel approach.
Where this research is happening
Fort Lauderdale-Davie, UNITED STATES
- Nova Southeastern University — Fort Lauderdale-Davie, United States (Active)
Researchers
- Principal investigator: Albensi, Benedict C — Nova Southeastern University
- Study coordinator: Albensi, Benedict C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.