Developing a new organoid tool to study and treat Alzheimer's disease.
Official title: Creating an sxRNA Organoid Product for Advancing the Study, Prevention and Treatment of Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD)
Funded at Sxrna Technologies, INC. · NIH-10765970 · Data updated 2026-11-12
This study is working on a special toolkit that uses tiny brain-like structures to help us learn more about Alzheimer's disease and find new treatments, which could ultimately help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sxrna Technologies, INC. NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $500,000 |
| NIH project number | 1R41AG081123-01A1 |
| Project ID | NIH-10765970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, as well as those at risk due to age or genetic factors.
✕Less likely to help
Patients with non-neurodegenerative forms of dementia or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on creating a toolkit of organoids that mimic human brain tissue to better understand Alzheimer's disease and related dementias. By using advanced 3D tissue cultures, researchers aim to identify senescent cells, which are believed to play a role in the aging process and neurodegeneration. The project will also facilitate high-throughput drug screening, allowing for the testing of potential treatments in a more realistic environment. Patients may benefit from insights gained into the mechanisms of Alzheimer's and the development of new therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related dementias.
How similar studies have gone: While the use of organoids in Alzheimer's research is a growing field, this specific approach utilizing sxRNA technology is relatively novel and has not been extensively tested.
Where this research is happening
-
Sxrna Technologies, INC.
Albany, United States Active
Researchers
- Principal investigator: Tenenbaum, Scott — Sxrna Technologies, INC.
- Study coordinator: Tenenbaum, Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.