Investigating how chemical exposures affect Alzheimer's disease and its progression
The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory
This study is looking at how things like your environment, genes, diet, and lifestyle affect brain health, especially in relation to Alzheimer's disease, and it invites patients to help researchers understand how their unique body chemistry connects to their thinking and memory.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10973577 on NIH RePORTER |
What this research studies
This research explores the impact of environmental factors, genetics, diet, and lifestyle on brain health, specifically focusing on Alzheimer's disease (AD) and related dementias. By utilizing advanced metabolomics and lipidomics technologies, along with genomic and imaging data, the study aims to identify metabolic changes that correlate with cognitive decline and brain imaging alterations. The project collaborates with various research centers to create a comprehensive molecular atlas that maps how these factors influence Alzheimer's disease progression. Patients may contribute to understanding how their individual metabolic profiles relate to their cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals at risk for Alzheimer's disease, those with early symptoms, or those with a family history of dementia.
Not a fit: Patients with advanced Alzheimer's disease or those not at risk for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and treatments for Alzheimer's disease by identifying key metabolic changes linked to the disease.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between metabolic changes and Alzheimer's disease, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — Duke University
- Study coordinator: Kaddurah-Daouk, Rima F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.