Investigating how chemical exposures affect Alzheimer's disease and its progression
Official title: The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory
Funded at Duke University · NIH-10973577 · Data updated 2026-11-12
This study is looking at how things like your environment, genes, diet, and lifestyle affect brain health, especially in relation to Alzheimer's disease, and it invites patients to help researchers understand how their unique body chemistry connects to their thinking and memory.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,499,382 |
| NIH project number | 1U01AG088562-01 |
| Project ID | NIH-10973577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals at risk for Alzheimer's disease, those with early symptoms, or those with a family history of dementia.
✕Less likely to help
Patients with advanced Alzheimer's disease or those not at risk for cognitive decline may not benefit from this research.
What this research studies
This research explores the impact of environmental factors, genetics, diet, and lifestyle on brain health, specifically focusing on Alzheimer's disease (AD) and related dementias. By utilizing advanced metabolomics and lipidomics technologies, along with genomic and imaging data, the study aims to identify metabolic changes that correlate with cognitive decline and brain imaging alterations. The project collaborates with various research centers to create a comprehensive molecular atlas that maps how these factors influence Alzheimer's disease progression. Patients may contribute to understanding how their individual metabolic profiles relate to their cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and treatments for Alzheimer's disease by identifying key metabolic changes linked to the disease.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between metabolic changes and Alzheimer's disease, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — Duke University
- Study coordinator: Kaddurah-Daouk, Rima F
Related research
Other NIH-funded projects on the same topics.
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Alzheimer’s disease and related brain changes linked to chemicals in the body
This NIH grant supports a patient-centered effort to map how environmental exposures and body chemistry relate to Alzheimer’s disease and related dementias.
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Understanding how everyday exposures affect Alzheimer's disease progression
A national research effort is studying how environmental exposures, gut health, diet, and metabolism relate to Alzheimer's and related dementias to identify new ways to diagnose and treat these conditions.
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How environment, gut health, and metabolism affect Alzheimer’s disease
This grant looks at how environmental exposures, gut microbes, diet, and metabolism influence Alzheimer’s disease and related dementias.
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Understanding how chemical exposures affect Alzheimer's disease progression
This project studies how environmental chemicals and other biological factors influence brain health and the course of Alzheimer’s disease and related dementias.
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Understanding how brain hyperexcitability and sex differences affect Alzheimer’s disease
This grant tests whether brain hyperexcitability linked to a genetic risk (APOE4) and sex differences contribute to memory decline in Alzheimer’s disease, using computer simulations and mouse data to guide potential human treatments.
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CNS Exosomes and Adaptive Immunity in Alzheimer’s Disease
This project studies how tiny brain vesicles called exosomes may activate the body's immune system in Alzheimer’s disease, with the goal of understanding mechanisms that could lead to new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.