Comparing two imaging systems for inherited retinal disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to compare the effectiveness of two ultrawide field imaging systems, Clarus and Optos, against a gold standard imaging system for evaluating inherited retinal diseases (IRDs). Participants aged 18 and older with a clinical or genetic diagnosis of IRD will undergo pupillary dilation and have their eyes photographed using all three imaging systems. The study seeks to determine if similar results and information can be obtained from these cameras for monitoring IRDs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants 18 years and older with a clinical and/ or genetic diagnosis of IRD recruited either from the clinic and/or the Inherited Ocular Disease Registry to participate in this trial
* Participants that are willing to participate as evidenced by signing the written informed consent

Exclusion Criteria:

* Presence of ocular conditions other than an IRD which may affect the quality of ocular imaging including but not limited to advanced cataracts, corneal disorders, nystagmus, vitreous hemorrhage, or poor dilation
* Presence of ocular conditions other than an IRD which may affect interpretation of retinal imagining including but not limited to epiretinal membrane, choroidal neovascular membrane, or macular scarring
* Patients with advanced IRDs who are unable to fixate for imaging
* Patients unable to tolerate ocular imaging
* Patients who do not wish to participate

Where it's running

• Department of Ophthalmology and Visual Sciences
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Kimberly Stepien, MD — University of Wisconsin, Madison
• Study coordinator: Angie Adler
• Email: amadler1@wisc.edu
• Phone: 608-265-7557

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Multimodal Eye Data Bank to Explore Inflammation-Related Eye Diseases

  This observational effort collects rich eye-imaging data from people with inflammatory and retinal conditions to see how the front and back of the eye relate and to build a standardized database that could support future AI tools.

  Recruiting Capital Medical University · Beijing · NCT07628946

• Tracking retinal changes over two years in people with moderate to early proliferative diabetic retinopathy

  This project will try to find imaging, functional, and blood markers that show whether retinopathy is getting worse over two years in people with type 2 diabetes and moderate-to-mildly advanced disease.

  Recruiting Association for Innovation and Biomedical Research on Light and Image · Coimbra · NCT07458516

• OCT data collection from healthy and diseased eyes (A10900)

  This project will collect Optical Coherence Tomography (OCT) scans from adults 22 and older who have retinal disease, glaucoma, corneal conditions, or are healthy to build a reference dataset for A10900.

  Recruiting at 3 sites Optos, PLC · Anaheim, California and 3 other locations · NCT07149740

• Choriocapillaris blood flow differences in people with pseudoxanthoma elasticum versus healthy adults

  We will test whether a noninvasive eye scan (OCT angiography) shows reduced choriocapillaris blood flow in adults with pseudoxanthoma elasticum compared with matched healthy adults.

  Recruiting University Hospital, Angers · Angers · NCT07006649

• Sepofarsen injections for LCA10 due to the CEP290 p.Cys998X mutation

  This study will test whether sepofarsen eye injections can improve vision in children and adults with LCA10 caused by the CEP290 c.2991+1655A>G (p.Cys998X) mutation.

  Recruiting at 17 sites Phase 3 Laboratoires Thea · San Francisco, California and 17 other locations · NCT06891443

• Auto-aligning handheld OCT for adult and pediatric retinal imaging

  We will test a new handheld OCT device that automatically aligns to capture retinal images in healthy adults, adult eye patients, and children.

  Recruiting Duke University · Durham, North Carolina · NCT06841575

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.