Understanding NF-kB to Improve Radiation Treatment for Cancer
Official title: Impact of Host NF-kB Signaling in Radiation Therapy
Funded at University of Wisconsin-Madison · NIH-11103273 · Data updated 2026-11-12
This research explores a new way to make radiation therapy more effective for cancer patients by focusing on how the body's immune system responds to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $376,455 |
| NIH project number | 5R01CA246321-05 |
| Project ID | NIH-11103273 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for cancer patients who may benefit from improved radiation therapy strategies in the future.
✕Less likely to help
Patients not undergoing radiation therapy or those with conditions unrelated to immune system responses to radiation may not directly benefit from this specific line of research.
What this research studies
Our bodies have a natural defense system, and a key part of it involves special immune cells called CD8 T cells that fight cancer. This project looks at a specific process within cells, called NF-kB signaling, which plays a role in how these immune cells work. We are learning how to adjust this process to help the immune system better recognize and destroy cancer cells during radiation therapy. The goal is to find ways to make radiation more powerful and create a lasting immune response against tumors.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that make radiation therapy more effective and potentially prevent cancer from returning by boosting the body's own immune defenses.
How similar studies have gone: This project builds on preliminary data and aims to uncover a surprising and crucial role for a specific cellular signaling pathway, suggesting a novel approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Miyamoto, Shigeki — University of Wisconsin-Madison
- Study coordinator: Miyamoto, Shigeki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.