Real-time, in-vivo dosimetry for safe FLASH radiation therapy in breast cancer
Official title: Active Real-Time Dosimetric Monitoring for FLASH Radiation Therapy in Cancer Treatment
Funded at Blue Physics LLC · NIH-11313733 · Data updated 2026-11-12
A real-time, safety-focused monitoring system using ultra-fast detectors to protect patients during FLASH radiation therapy for breast cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Blue Physics LLC NIH-funded |
| Lab location | 1 site (Lutz, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $405,632 |
| NIH project number | 1R41CA310202-01 |
| Project ID | NIH-11313733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with breast cancer considered for radiotherapy who would benefit from improved dose verification during treatment.
✕Less likely to help
The system is a safety enhancement; patients not undergoing FLASH therapy or those not receiving radiotherapy would not benefit.
What this research studies
This project aims to create a fast, in-vivo dosimetry system that watches dose delivery during FLASH radiotherapy and can immediately halt treatment if limits are exceeded. It will use two fast scintillation materials to estimate dose without frequent recalibration and will be paired with software to control the radiation beam in real time. The team will test the prototype on phantoms designed to mimic human anatomy and verify measurements against established dosimetry methods. If successful, this technology could make ultra-high-dose-rate therapy safer and more practical for breast cancer patients.
Why it matters
Potential benefit: If successful, patients could receive FLASH therapy with a built-in safety net that reduces the risk of overdose and improves treatment precision.
How similar studies have gone: Previous work in dosimetry and real-time monitoring supports the concept, but this specific real-time MDR-based correction approach is novel.
Where this research is happening
-
Blue Physics LLC
Lutz, United States Active
Researchers
- Principal investigator: Feijoo, Marcos Andres — Blue Physics LLC
- Study coordinator: Feijoo, Marcos Andres
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.