Using MRI to improve radiation therapy planning and response assessment
Development and Evaluation of Imaging Acquisition and Analysis Methods for Optimization of MRI and/or CT in Radiation Oncology Simulation, Treatment Planning, and Response Assessment
This study is testing new MRI and CT imaging techniques to see if they can help cancer patients get better radiation therapy and understand how well their treatment is working.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 837 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Drugs / interventions | Radiation |
| Locations | 7 sites (Basking Ridge, New Jersey and 6 other locations) |
| Trial ID | NCT02422550 on ClinicalTrials.gov |
What this trial studies
This study explores the use of advanced MRI and CT imaging techniques to enhance the planning and assessment of radiation therapy for cancer patients. It aims to demonstrate the feasibility of new imaging hardware and software, including the MR-Linac, which integrates radiation treatment with MRI scanning. By modifying pulse sequences and imaging protocols, the research seeks to improve the quality of MRI-guided radiation treatment and assess tumor responses more effectively. The study will involve ongoing evaluations of these imaging technologies to facilitate their clinical application.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are undergoing radiation therapy.
Not a fit: Patients who cannot undergo MRI due to medical contraindications, such as having a pacemaker or being pregnant, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more precise and effective radiation therapy for cancer patients, improving treatment outcomes.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for radiation therapy, but this specific approach with the MR-Linac is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women age 18 or older Exclusion Criteria: * Anyone who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire * Participants/volunteers with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field * Female participants/volunteers who are pregnant or nursing * Participants/Volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety * Participants/Volunteers from the vulnerable population, as defined by 45 CFR 46. * Participants at higher risk due to age, frailty, or the emergent nature of their condition.
Where this trial is running
Basking Ridge, New Jersey and 6 other locations
- Memorial Sloan Kettering Basking Ridge (Consent only) — Basking Ridge, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Monmouth (Consent only) — Middletown, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Bergen (Consent only ) — Montvale, New Jersey, United States (Recruiting)
- Memorial Sloan Kettering Commack (Consent Only) — Commack, New York, United States (Recruiting)
- Memorial Sloan Kettering Westchester (Consent only) — Harrison, New York, United States (Recruiting)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (Recruiting)
- Memorial Sloan Kettering Nassau (Consent only) — Uniondale, New York, United States (Recruiting)
Study contacts
- Principal investigator: Nancy Lee, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Nancy Lee, MD
- Phone: 212-639-3341
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.