Coordinated support for depression during and after pregnancy

Collaborative Care Model for Perinatal Depression Support Services – Population-Level Upstream Systems Change (COMPASS-PLUS): A Hybrid Type 2 Cluster Randomized Trial

NIH-funded research Women and Infants Hospital-Rhode Island · NIH-11121079

A collaborative care approach to help pregnant and postpartum people get better screening, treatment, and follow-up for depression.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWomen and Infants Hospital-Rhode Island NIH-funded
Lab location1 site (Providence, United States)
Project IDNIH-11121079 on NIH RePORTER

What this research studies

This project works with obstetric clinics to bring mental health care into routine pregnancy and postpartum visits through a collaborative care team that links obstetric providers, mental health specialists, and community supports. Clinics are randomly assigned to adopt the COMPASS-PLUS team-based model or continue usual care, and outcomes are tracked at both the clinic and patient level. Researchers will measure patient outcomes such as treatment initiation and symptom remission as well as how well the new system is adopted across diverse communities. The trial aims to reduce racial and ethnic gaps in perinatal mental health care by changing upstream systems so more people get coordinated, timely support.

Who could benefit from this research

Good fit: Ideal candidates are pregnant or postpartum people who receive care at participating obstetric clinics and who screen positive for or have symptoms of perinatal depression.

Not a fit: People who are not pregnant or postpartum, who do not receive care at participating clinics, or who require immediate inpatient or crisis psychiatric care are unlikely to benefit directly from this trial.

Why it matters

Potential benefit: If successful, more pregnant and postpartum people could get timely diagnosis, coordinated treatment, and symptom improvement, which may lower maternal morbidity and mortality.

How similar studies have performed: Collaborative care has improved depression outcomes in general medical settings and in some smaller perinatal studies, but this large cluster randomized effort to change clinic systems is relatively new.

Where this research is happening

Providence, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.