Coordinated support for depression during and after pregnancy
Official title: Collaborative Care Model for Perinatal Depression Support Services – Population-Level Upstream Systems Change (COMPASS-PLUS): A Hybrid Type 2 Cluster Randomized Trial
Funded at Women and Infants Hospital-Rhode Island · NIH-11121079 · Data updated 2026-11-12
A collaborative care approach to help pregnant and postpartum people get better screening, treatment, and follow-up for depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Women and Infants Hospital-Rhode Island NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 19, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $743,655 |
| NIH project number | 5R01NR021126-03 |
| Project ID | NIH-11121079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are pregnant or postpartum people who receive care at participating obstetric clinics and who screen positive for or have symptoms of perinatal depression.
✕Less likely to help
People who are not pregnant or postpartum, who do not receive care at participating clinics, or who require immediate inpatient or crisis psychiatric care are unlikely to benefit directly from this trial.
What this research studies
This project works with obstetric clinics to bring mental health care into routine pregnancy and postpartum visits through a collaborative care team that links obstetric providers, mental health specialists, and community supports. Clinics are randomly assigned to adopt the COMPASS-PLUS team-based model or continue usual care, and outcomes are tracked at both the clinic and patient level. Researchers will measure patient outcomes such as treatment initiation and symptom remission as well as how well the new system is adopted across diverse communities. The trial aims to reduce racial and ethnic gaps in perinatal mental health care by changing upstream systems so more people get coordinated, timely support.
Why it matters
Potential benefit: If successful, more pregnant and postpartum people could get timely diagnosis, coordinated treatment, and symptom improvement, which may lower maternal morbidity and mortality.
How similar studies have gone: Collaborative care has improved depression outcomes in general medical settings and in some smaller perinatal studies, but this large cluster randomized effort to change clinic systems is relatively new.
Where this research is happening
-
Women and Infants Hospital-Rhode Island
Providence, United States Active
Researchers
- Principal investigator: Miller, Emily Stinnett — Women and Infants Hospital-Rhode Island
- Study coordinator: Miller, Emily Stinnett
Related research
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Understanding how gut and body signals interact to influence perinatal depression
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.